# Educational Case: Mesothelioma

**Authors:** Kassaye Firde, Deborah J. Chute

PMC · DOI: 10.1016/j.acpath.2025.100239 · Academic Pathology · 2026-02-10

## Full-text entities

- **Genes:** HEG1 (heart development protein with EGF like domains 1) [NCBI Gene 57493] {aka HEG, MST112, MSTP112}, PAX8 (paired box 8) [NCBI Gene 7849] {aka PAX-8}, NAPSA (napsin A aspartic peptidase) [NCBI Gene 9476] {aka KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, TTF1 (transcription termination factor 1) [NCBI Gene 7270] {aka TTF-1, TTF-I}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, IL9 (interleukin 9) [NCBI Gene 3578] {aka HP40, IL-9, P40}, BAP1 (BRCA1 associated deubiquitinase 1) [NCBI Gene 8314] {aka HUCEP-13, KURIS, TPDS1, UBM2, UCHL2, UVM2}, PPIG (peptidylprolyl isomerase G) [NCBI Gene 9360] {aka CARS-Cyp, CYP, SCAF10, SRCyp}, CLDN4 (claudin 4) [NCBI Gene 1364] {aka CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R}, WT1 (WT1 transcription factor) [NCBI Gene 7490] {aka AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1}, PDPN (podoplanin) [NCBI Gene 10630] {aka AGGRUS, D2-40, GP36, GP40, Gp38, HT1A-1}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, CALB2 (calbindin 2) [NCBI Gene 794] {aka CAB29, CAL2, CR}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}
- **Diseases:** connective tissue diseases (MESH:D003240), blood (MESH:D006402), synovial sarcoma (MESH:D013584), metastasis (MESH:D009362), cough (MESH:D003371), chest trauma (MESH:D013898), reactive mesothelial (MESH:D018301), epithelioid hemangioendothelioma (MESH:D018323), infection (MESH:D007239), effusion (MESH:D000080324), exudates (MESH:D011504), pneumothorax (MESH:D011030), desmoplastic (MESH:D018220), Biphasic mesotheliomas (MESH:D008654), serosal malignancy (MESH:D012700), breast or ovarian (MESH:D010051), metastatic carcinoma (MESH:C538445), Primary lymphomas (MESH:D008223), type II diabetes mellitus (MESH:D003924), breast cancer (MESH:D001943), congestive heart failure (MESH:D006333), chondrosarcoma (MESH:D002813), sarcomatoid (MESH:D002292), chronic (MESH:D002908), Solitary fibrous tumor (MESH:D054364), pleuropulmonary blastoma (MESH:C537516), cardiac abnormalities (MESH:D018376), Diffuse large B-cell lymphoma (MESH:D016403), necrosis (MESH:D009336), Primary effusion lymphoma (MESH:D054685), pain (MESH:D010146), pulmonary infarction (MESH:D054060), nephrotic syndrome (MESH:D009404), desmoplastic round cell sarcoma (MESH:D058405), inflammation (MESH:D007249), calcifying fibrous tumor (MESH:C537961), osteosarcomas (MESH:D012516), chronic liver disease (MESH:D008107), H&E (MESH:D016751), trauma (MESH:D014947), oligometastatic disease (MESH:D004194), cirrhosis (MESH:D005355), pulmonary edema (MESH:D011654), Metastatic (MESH:D000092182), tumor predisposition syndrome (OMIM:614327), lung carcinoma (MESH:D008175), shortness of breath (MESH:D004417), desmoid-type fibromatosis (MESH:D018222), empyema (MESH:D004653), serous carcinoma (MESH:D018297), pleural (MESH:D010995), lymphatic abnormalities (MESH:D044148), carcinoma (MESH:D009369), calcification (MESH:D002114), Adenocarcinoma (MESH:D000230), pyothorax (MESH:D016724), airway disease (MESH:D029424), pneumonia (MESH:D011014), hypoalbuminemia (MESH:D034141), Pleural effusions (MESH:D010996)
- **Chemicals:** Cytospin (-), H&E (MESH:D006371), asbestos (MESH:D001194), glucose (MESH:D005947), oxygen (MESH:D010100), amosite (MESH:D017639), Erionite (MESH:C083174), crocidolite (MESH:D017638), water (MESH:D014867)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human gammaherpesvirus 8 (no rank) [taxon 37296], Meleagris gallopavo (common turkey, species) [taxon 9103], Human immunodeficiency virus 1 (no rank) [taxon 11676]
- **Cell lines:** MOC-31 — Mus musculus (Mouse), Squamous cell carcinoma of the mouse oral cavity, Cancer cell line (CVCL_ZD33)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12914656/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12914656/full.md

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Source: https://tomesphere.com/paper/PMC12914656