# Paratesticular sarcoma of the spermatic cord: A rare case of dedifferentiated leiomyosarcoma

**Authors:** Resul Çi̇çek, İbrahim Topçu, Bulut Dural, Serhat Toprak, Ömer Faruk Yıldırım, Yasin Karaçor

PMC · DOI: 10.1016/j.eucr.2026.103372 · Urology Case Reports · 2026-02-09

## TL;DR

This paper reports a rare case of paratesticular sarcoma diagnosed as dedifferentiated liposarcoma, emphasizing the need for thorough evaluation and complete surgical removal.

## Contribution

The novelty lies in presenting a rare case with detailed histopathological and immunohistochemical findings for accurate diagnosis.

## Key findings

- The tumor was diagnosed as dedifferentiated liposarcoma after comprehensive evaluation.
- Radical inguinal orchiectomy was performed for treatment.
- Comprehensive pathological evaluation is crucial for accurate diagnosis and management.

## Abstract

Paratesticular sarcomas are extremely rare tumors characterized by aggressive biological behavior and a significant risk of recurrence and metastasis. We present a rare case of paratesticular sarcoma ultimately diagnosed as dedifferentiated liposarcoma following comprehensive histopathological and immunohistochemical evaluation. The patient presented with complaints of scrotal edema and discomfort, and radical inguinal orchiectomy was performed. The definitive diagnosis was established through comprehensive histological and immunohistochemical evaluation and was defined as dedifferentiated liposarcoma. This report emphasizes the critical importance of comprehensive pathological evaluation and highlights total surgical excision as the primary approach in the treatment of paratesticular sarcomas due to their rarity and complex diagnosis

## Linked entities

- **Diseases:** dedifferentiated liposarcoma (MONDO:0020563)

## Full-text entities

- **Genes:** DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, CDK4 (cyclin dependent kinase 4) [NCBI Gene 1019] {aka CMM3, MCPH31, PSK-J3}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, VIM (vimentin) [NCBI Gene 7431], CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}
- **Diseases:** epididymal cysts (MESH:D013088), metastases (MESH:D009362), male genitourinary cancers (MESH:D014565), scrotal lump (MESH:D014063), hernias (MESH:D006547), soft (MESH:C562950), male genitourinary malignancies (MESH:D052801), scrotal soreness (MESH:D063806), necrosis (MESH:D009336), Dedifferentiated liposarcoma (MESH:D008080), inguinal hernias (MESH:D006552), lipomas (MESH:D008067), Leiomyosarcoma (MESH:D007890), benign paratesticular diseases (MESH:D004194), scrotal edema (MESH:D004487), fibrosarcoma (MESH:D005354), Tumoral (MESH:D009369), spermatic cord leiomyosarcoma (MESH:D013086), malignant mesenchymal tumors (MESH:C535700), Paratesticular sarcoma (MESH:D012509)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12914520/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12914520/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12914520/full.md

---
Source: https://tomesphere.com/paper/PMC12914520