# Glycolysis enzymes and cellular lactylation in tumour

## TL;DR

This paper reviews how glycolysis enzymes affect lactylation in cancer cells, influencing tumor growth and suggesting lactylation as a potential cancer therapy target.

## Contribution

The paper provides a comprehensive review of the role of glycolytic enzymes in regulating lactylation and its implications for tumor biology.

## Key findings

- Glycolytic enzymes modulate lactylation in cancer cells.
- Lactylation promotes tumor growth, metastasis, and immune evasion.
- Targeting lactylation is a promising strategy for cancer therapy.

## Abstract

Cellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer. The discovery of lactylation provides a new perspective for understanding the functional significance of the Warburg effect in tumour cells. Enzymes involved in the glycolytic pathway modulate lactylation, influencing tumour genesis and progression. This review explores the intricate relationship between glycolysis, lactylation and tumour biology, with a focus on how enzymes participating in glycolysis impact lactylation in cancer cells. We discuss how glycolytic enzymes regulate lactylation and highlight their broader implications in tumour biology. The role of lactylation in shaping the tumour microenvironment underscores its increasing significance as a biomarker for cancer prognosis and a target for therapeutic intervention. Therefore, we also summarised the potential of targeting lactylation as a cancer therapy strategy.

Glycolytic enzymes regulate lactylation in cancer cells.Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodellingTargeting lactylation holds promise for cancer therapy.

Glycolytic enzymes regulate lactylation in cancer cells.

Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling

Targeting lactylation holds promise for cancer therapy.

Graphical Headlights

• Glycolytic enzymes regulate lactylation in cancer cells.

• Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling.

• Targeting lactylation holds promise for cancer therapy.