# Solitary Hepatic Metastasis of Thymoma: A Case Report

**Authors:** Hiroshi Sakai, Yoshiaki Tominaga, Kazuya Yoshida, Ian Fukudome, Yoshiki Mizukami, Tomofumi Watanabe, Kenji Sano, Manabu Hiraguri

PMC · DOI: 10.70352/scrj.cr.25-0400 · Surgical Case Reports · 2026-02-13

## TL;DR

This case report describes a patient who had surgery for a rare liver metastasis from a thymoma, highlighting the need for more data on surgical treatment options.

## Contribution

The paper presents a rare case of surgical resection for a solitary liver metastasis from a thymoma.

## Key findings

- The patient had a type B3 thymoma that metastasized to the liver 18 months after initial surgery.
- Surgical resection of the hepatic lesion was performed with no recurrence observed during follow-up.
- More cases are needed to establish evidence-based guidelines for treating liver metastases from thymomas.

## Abstract

Hepatic recurrence of thymomas is uncommon and its surgical treatment has rarely been reported. We report the case of a patient who underwent surgical resection for a solitary liver metastasis of a thymoma.

A 61-year-old female presented with an abnormal shadow on chest radiography performed during a medical checkup. CT revealed an 85-mm mass in the anterior mediastinum, adjacent to the pericardium and the right upper and right middle lobes of the lung. The patient underwent total thymectomy, wedge resection of the upper and middle lobes of the right lung, and partial resection of the pericardium. Histopathology revealed a type B3 thymoma, classified as stage II according to the Masaoka staging system. An abdominal CT performed 18 months after the primary surgery revealed a 34-mm solid mass in the 6th liver segment. Wedge resection of the hepatic lesion was performed. Pathological examination revealed liver metastasis of a type B3 thymoma. No recurrence was observed during follow-up.

The paucity of data on the surgical treatment of liver metastases from thymomas hinders the establishment of clear evidence-based guidelines for determining the indications for surgical intervention. Surgery appears to be the most appropriate treatment for solitary liver metastasis; however, the most efficacious treatment remains to be elucidated. It is necessary to accumulate more cases of patients who have undergone hepatectomy for liver metastasis of thymoma.

## Linked entities

- **Diseases:** thymoma (MONDO:0006456)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** CD5 (CD5 molecule) [NCBI Gene 921] {aka LEU1, T1}, DNTT (DNA nucleotidylexotransferase) [NCBI Gene 1791] {aka TDT}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}
- **Diseases:** cysts (MESH:D003560), liver tumor (MESH:D008113), myasthenia gravis (MESH:D009157), substernal goiters (MESH:D006045), necrosis (MESH:D009336), thymic epithelial tumors (MESH:C536905), Thymoma (MESH:D013945), hepatic lesion (MESH:D056486), liver (MESH:D017093), Thymic Malignancy (MESH:D013953), anterior mediastinal masses (MESH:D008480), hemorrhage (MESH:D006470), PRESENTATION (MESH:D001946), B3 (OMIM:120050), malignant diseases (MESH:D009369), Hepatic Metastasis (MESH:D009362), hematoma (MESH:D006406)
- **Chemicals:** gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (MESH:C073590), eosin (MESH:D004801), water (MESH:D014867), 18F-FDG (MESH:D019788), Hematoxylin (MESH:D006416), 18F-fluorodoeoxyglucose (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12914097/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12914097/full.md

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Source: https://tomesphere.com/paper/PMC12914097