# Stanford Type B Aortic Dissection in a Twin Pregnancy With Marfan Syndrome: A Rare Obstetric Emergency—A Case Report

**Authors:** Oxana M. Zarudskaya, Alixandria F. Pfeiffer, Angela R. Boyd, John J. Byrne, Patrick Ramsey, Ildiko Agoston

PMC · DOI: 10.1155/crog/4069281 · Case Reports in Obstetrics and Gynecology · 2026-02-17

## TL;DR

A rare case of Type B aortic dissection in a pregnant twin with Marfan syndrome highlights the need for thorough aortic evaluation during pregnancy.

## Contribution

This case report emphasizes the importance of whole aorta imaging in pregnant patients with Marfan syndrome.

## Key findings

- A pregnant patient with Marfan syndrome developed Type B aortic dissection in the third trimester.
- Initial prenatal assessments showed normal results despite later complications.
- Comprehensive aortic imaging is crucial for managing high-risk pregnancies in MFS patients.

## Abstract

The physiologic changes of pregnancy make pregnant women with Marfan syndrome (MFS) more vulnerable to complications of aortic disease. Significant hemodynamic changes in the third trimester and postpartum may explain the increased susceptibility to aortic complications during this time frame. The rate of cardiovascular complications in MFS is 2%–6%. We presented a case of Type B aortic dissection in a pregnant patient with MFS in the third trimester and normal evaluation at the initial prenatal assessment. This case report highlights the importance of comprehensive evaluation during pregnancy and the consideration of whole aorta imaging in addition to the routine transthoracic echocardiographic assessment of the aortic root.

## Linked entities

- **Diseases:** Marfan syndrome (MONDO:0007947)

## Full-text entities

- **Genes:** FBN1 (fibrillin 1) [NCBI Gene 2200] {aka ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS}
- **Diseases:** atrium septal defect (MESH:D006343), aortic root dilation (MESH:D000094628), cardiac disease (MESH:D006331), glaucoma (MESH:D005901), cardiovascular complications (MESH:D002318), aneurysmal dilatation (MESH:D002311), sudden death (MESH:D003645), nausea (MESH:D009325), MFS (MESH:D008382), chest pain (MESH:D002637), cervical dilation (MESH:D002575), vomiting (MESH:D014839), hematoma (MESH:D006406), aortic disease (MESH:D001018), aortic complications (MESH:D008107), atrial septal defect (MESH:D006344), GERD (MESH:D005764), pain (MESH:D010146), weakness of the arterial wall (MESH:D018908), Dissection (MESH:D000784), thoracic aortic disease (MESH:D013896), blood loss (MESH:D016063), Stanford Type B (MESH:D006509), autosomal dominant condition (MESH:C566739), mitral valve prolapse (MESH:D008945)
- **Chemicals:** Labetalol (MESH:D007741), alcohol (MESH:D000438), Valsalva (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12914084/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12914084/full.md

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Source: https://tomesphere.com/paper/PMC12914084