# Direct Ice Packing for Voice Changes During Thyroid Radiofrequency Ablation: A Retrospective Case Series

**Authors:** Mei-Chen Yeh, Wei-Shin Yu, Hsiang-Lin Lee, Yu-Shen Lee, Kai-Lun Cheng

PMC · DOI: 10.1155/crie/7160959 · Case Reports in Endocrinology · 2026-02-17

## TL;DR

This study explores using ice packs to quickly resolve voice changes caused by thyroid radiofrequency ablation, showing promising results in a small group of patients.

## Contribution

The paper introduces direct ice packing as a novel, noninvasive intervention for managing voice changes during thyroid radiofrequency ablation.

## Key findings

- All five patients experienced complete resolution of voice changes within 20–50 minutes after ice packing.
- No cold-induced skin injury or additional treatment was required in any patient.
- Voice improvement was rapid, suggesting ice packing is a safe and practical management option.

## Abstract

Voice change is a recognized complication of radiofrequency ablation (RFA) for thyroid nodules, primarily resulting from thermal injury to the recurrent laryngeal nerve or adjacent structures. Although most cases resolve spontaneously over several weeks to months, timely intervention may help reduce patient discomfort and anxiety. This retrospective case series examined five patients who developed voice changes during or immediately after RFA for benign thyroid nodules and were managed with direct ice packing. Ipsilateral vocal cord (VC) hypomobility was confirmed via real‐time laryngeal ultrasound, followed by immediate application of ice to the skin overlying the thyroid. VC movement and skin integrity were assessed every 10 min. All patients achieved complete symptom resolution within 20–50 min (median: 30 min) without complications. No cold‐induced skin injury occurred, and no additional treatment was required. While spontaneous recovery cannot be excluded, the relatively rapid improvement observed in this series suggests that direct ice packing may represent a safe, practical, and noninvasive management option for RFA‐related voice changes. Further studies are warranted to confirm its efficacy in larger and more diverse populations.

## Full-text entities

- **Diseases:** anxiety (MESH:D001007), TA (MESH:D020886), benign (MESH:D009369), changes (MESH:D009402), neural irritation (MESH:D001523), skin injuries (MESH:D000069836), nerve damage (MESH:D000080902), thyroid cancer (MESH:D013964), Nodule (MESH:D016606), alteration (MESH:D004408), frostbite (MESH:D005627), thyroid TA (MESH:D013966), VC (MESH:D014826)
- **Chemicals:** lidocaine (MESH:D008012), ice (MESH:D007053), dextrose (MESH:D005947), water (MESH:D014867)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12914082/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12914082/full.md

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Source: https://tomesphere.com/paper/PMC12914082