# A novel necroptosis pathway: orchestrated by non-canonical STING-ZBP1 signaling

**Authors:** Xiangyu Zhu, Sijia Liu, Long Zhang

PMC · DOI: 10.1038/s41392-026-02587-7 · Signal Transduction and Targeted Therapy · 2026-02-18

## Full-text entities

- **Genes:** Zbp1 (Z-DNA binding protein 1) [NCBI Gene 58203] {aka 2010010H03Rik, Dai, Dlm1, mZaDLM}, Stat1 (signal transducer and activator of transcription 1) [NCBI Gene 20846] {aka 2010005J02Rik}, Tbk1 (TANK-binding kinase 1) [NCBI Gene 56480] {aka 1200008B05Rik}, Sting1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 72512] {aka 2610307O08Rik, ERIS, MPYS, Mita, STING, STING-beta}, Casp8 (caspase 8) [NCBI Gene 12370] {aka CASP-8, FLICE, MACH, Mch5}, Mlkl (mixed lineage kinase domain-like) [NCBI Gene 74568] {aka 9130019I15Rik}, Il1b (interleukin 1 beta) [NCBI Gene 16176] {aka IL-1beta, Il-1b}, MLKL (mixed lineage kinase domain like pseudokinase) [NCBI Gene 197259] {aka hMLKL}, RIPK3 (receptor interacting serine/threonine kinase 3) [NCBI Gene 11035] {aka RIP3}, STING1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 340061] {aka ERIS, MITA, MPYS, NET23, SAVI, STING}, Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) [NCBI Gene 19766] {aka D330015H01Rik, RIP, RIP-1, Rinp, Rip1}, Fadd (Fas associated via death domain) [NCBI Gene 14082] {aka Mort1/FADD}, Il21 (interleukin 21) [NCBI Gene 60505] {aka IL-21}, FADD (Fas associated via death domain) [NCBI Gene 8772] {aka GIG3, IMD90, MORT1}, Ripk3 (receptor-interacting serine-threonine kinase 3) [NCBI Gene 56532] {aka 2610528K09Rik, Rip3}, Cxcl1 (C-X-C motif chemokine ligand 1) [NCBI Gene 14825] {aka Fsp, Gro1, KC, Mgsa, N51, Scyb1}, CGAS (cyclic GMP-AMP synthase) [NCBI Gene 115004] {aka C6orf150, D4, MB21D1, h-cGAS}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, CASP8 (caspase 8) [NCBI Gene 841] {aka ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5}, TNFRSF1A (TNF receptor superfamily member 1A) [NCBI Gene 7132] {aka CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55}, Irf3 (interferon regulatory factor 3) [NCBI Gene 54131] {aka C920001K05Rik, IRF-3}, ZBP1 (Z-DNA binding protein 1) [NCBI Gene 81030] {aka C20orf183, DAI, DLM-1, DLM1}, Cgas (cyclic GMP-AMP synthase) [NCBI Gene 214763] {aka E330016A19Rik, Mb21d1}, Tnfrsf1a (tumor necrosis factor receptor superfamily, member 1a) [NCBI Gene 21937] {aka CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55}
- **Diseases:** vasculopathy (MESH:D000090122), vascular disease (MESH:D014652), diseases (MESH:D004194), inflammation (MESH:D007249), skin lesions (MESH:D012871), cutaneous lesions (MESH:D009059), autoimmune diseases (MESH:D001327), dermatitis (MESH:D003872), pulmonary inflammation (MESH:D011014), infection (MESH:D007239), mitotic abnormalities (MESH:C536987), SAVI (OMIM:615934), necrosis (MESH:D009336), immune cell abnormalities (MESH:D002292), interstitial lung disease (MESH:D017563)
- **Chemicals:** DMXAA (MESH:C066668), cGAMP (MESH:C584311), C-178 (-), Z (MESH:C000597310)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12913958