# Revisiting Ravn virus as the lesser known orthomarburgvirus **Authors:** Ivet A. Yordanova, Joseph B. Prescott PMC · DOI: 10.1038/s44298-026-00180-x · npj Viruses · 2026-02-17 ## TL;DR This paper reviews Ravn virus, a close relative of Marburg virus, focusing on its genetics, transmission, and vaccine development. ## Contribution The paper provides a comprehensive review of Ravn virus, highlighting its distinct characteristics and research gaps. ## Key findings - Ravn virus differs from Marburg virus by 21% at the nucleotide level and 22% at the protein level. - The paper summarizes current knowledge on Ravn virus epidemiology, animal models, and vaccine development. - Outstanding questions about Ravn virus life history and pathogenicity are identified. ## Abstract Marburg virus (MARV) is a highly pathogenic zoonotic filovirus. The Orthomarburgvirus marburgense species includes MARV and Ravn virus (RAVV), which differs from MARV by 21% at the nucleotide level and 22% at the protein level. This review offers fresh discussions of the epidemiology, genetics and natural reservoir transmission of RAVV, summarizes experimental animal models, outlines current vaccine development and raises outstanding questions about RAVV life history, transmission and pathogenicity. ## Full-text entities - **Genes:** GP2 [NCBI Gene 100730782], MCP-1 [NCBI Gene 100135494], STAT2 [NCBI Gene 100719719], CXCL10 [NCBI Gene 100714889], RNF130 (ring finger protein 130) [NCBI Gene 55819] {aka G1RP, G1RZFP, GOLIATH, GP}, IL-8 [NCBI Gene 100379599], IL-6 [NCBI Gene 106027696] - **Diseases:** hemorrhage (MESH:D006470), petechial rashes (MESH:D005076), Viremia (MESH:D014766), filovirus (MESH:D018702), hepatic lesions (MESH:D056486), necrosis (MESH:D009336), hemorrhagic fever diseases (MESH:D006482), lymphocytosis (MESH:D008218), fever (MESH:D005334), malaria (MESH:D008288), vomiting (MESH:D014839), SCID (MESH:D016511), hemorrhagic diathesis (MESH:D006474), headaches (MESH:D006261), inflammation (MESH:D007249), shock (MESH:D012769), neutrophilia (MESH:C563010), MARV (MESH:D008379), RAVV infection (MESH:D014777), fatalities (MESH:C565541), thrombocytopenia (MESH:D013921), hepatocellular necrosis (MESH:D047508), lymphopenia (MESH:D008231), Infection (MESH:D007239), coagulation abnormalities (MESH:D001778), multiorgan failure (MESH:D051437), acute hepatocellular and follicular necrosis (MESH:D015882), anorexia (MESH:D000855), weight loss (MESH:D015431), lethargy (MESH:D053609) - **Chemicals:** L (MESH:D007930), lipid (MESH:D008055), creatinine (MESH:D003404), gold (MESH:D006046), MR191 (-), N (MESH:D009584) - **Species:** Marburg [taxon 186537], Filoviridae (family) [taxon 11266], Ixodida (ticks, order) [taxon 6935], Rousettus aegyptiacus (Egyptian rousette, species) [taxon 9407], Molossidae (free-tailed bats, family) [taxon 9436], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Kasokero virus (no rank) [taxon 1712570], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Hendra virus [taxon 63330], Venezuelan equine encephalitis virus (no rank) [taxon 11036], Bacillus sp. AT (species) [taxon 1196779], Pteropodidae (flying foxes, family) [taxon 9398], Rhinolophus (genus) [taxon 49442], Chiroptera (bats, order) [taxon 9397], Rhinolophus eloquens (Eloquent horseshoe bat, species) [taxon 519038], Callithrix jacchus (common marmoset, species) [taxon 9483], Reston ebolavirus (no rank) [taxon 186539], Macaca mulatta (rhesus macaque, species) [taxon 9544], Sudan ebolavirus (no rank) [taxon 186540], Tai Forest ebolavirus (no rank) [taxon 186541], Ebola virus (no rank) [taxon 1570291], Macaca fascicularis (crab eating macaque, species) [taxon 9541], Bundibugyo virus (no rank) [taxon 565995], Adenoviridae (family) [taxon 10508], Mus musculus (house mouse, species) [taxon 10090], Sosuga virus (no rank) [taxon 1452514], Chlorocebus aethiops (African green monkey, species) [taxon 9534], Homo sapiens (human, species) [taxon 9606], Cuevavirus (genus) [taxon 1513236], Reticulinasus faini (species) [taxon 1811739], Mustela putorius furo (black ferret, subspecies) [taxon 9669], Cricetus cricetus (black-bellied hamster, species) [taxon 10034], Cricetinae (hamsters, subfamily) [taxon 10026] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12913732/full.md ## Figures 4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12913732/full.md ## References 5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913732/full.md --- Source: https://tomesphere.com/paper/PMC12913732