# A Rare Case of Prosthetic Joint Infection Caused by Group D Salmonella

**Authors:** Anna Barbiero, Lucia Graziani, Matteo Piccica, Francesco Raspanti, Luigi Zanna, Marco Mugnaini, Letizia Attala, Massimo Antonio Di Pietro

PMC · DOI: 10.1155/crdi/7477436 · Case Reports in Infectious Diseases · 2026-02-17

## TL;DR

A rare case of knee infection from Group D Salmonella was successfully treated with surgery and antibiotics, highlighting the importance of collaboration between specialists.

## Contribution

Reports a rare case of knee PJI caused by Group D Salmonella and its successful treatment strategy.

## Key findings

- Knee prosthetic joint infections caused by Group D Salmonella are extremely rare.
- Two-stage revision surgery and targeted antibiotic therapy based on susceptibility testing led to successful treatment.
- Collaboration between orthopedic and infectious disease specialists is critical for managing such infections.

## Abstract

Prosthetic joint infections (PJIs) are gaining growing attention as a healthcare issue. Salmonella spp. is a rare cause of PJI, mostly involving hip arthroplasty rather than knee arthroplasty. Therefore, clinical experience on the management of PJI involving knee arthroplasties caused by Salmonella spp. is scant. We report a case of knee PJI caused by Group D Salmonella, successfully treated with a two‐stage revision surgery and appropriate antibiotic therapy, based on antimicrobial susceptibility of the cultural isolate. Such challenging cases evidence that clinical success is achievable through appropriate medical and surgical management, combined with a strong collaboration between orthopedics and infectious disease specialists.

## Linked entities

- **Diseases:** Salmonella infection (MONDO:0000827)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** infectious disease (MESH:D003141), Staphylococcus capitis (MESH:D013203), fistula (MESH:D005402), septic arthritis (MESH:D001170), allergies (MESH:D004342), osteomyelitis (MESH:D010019), leukocytosis (MESH:D007964), SARS-CoV-2 infection (MESH:D000086382), Prosthetic Joint Infection (MESH:D007239), Wegner's granulomatosis (MESH:D014890), neutropenia (MESH:D009503), hypothyroidism (MESH:D007037), TKA (MESH:D007718), anaphylactic shock (MESH:D000707), systemic lupus erythematosus (MESH:D008180), thalassemia (MESH:D013789), osteoarthritis (MESH:D010003), total (MESH:C535338), swelling (MESH:D004487), asthma (MESH:D001249), diabetes (MESH:D003920), PJI (MESH:C537702), gastroenteritis (MESH:D005759), reactive arthritis (MESH:D016918), Pain (MESH:D010146), fracture (MESH:D050723), gastrointestinal symptoms (MESH:D012817), leucopenia (MESH:C536227), abscess (MESH:D000038), inflammation (MESH:D007249)
- **Chemicals:** povidone-iodine (MESH:D011206), TMP-SMX (MESH:D015662), ampicillin (MESH:D000667), fluoroquinolones (MESH:D024841), cephalosporins (MESH:D002511), penicillin (MESH:D010406), Cefotaxime (MESH:D002439), TJAs (-), hydrogen peroxide (MESH:D006861), gentamicin (MESH:D005839), ertapenem (MESH:D000077727), Ciprofloxacin (MESH:D002939), amoxicillin/clavulanate (MESH:D019980), aminoglycosides (MESH:D000617)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Salmonella enterica subsp. enterica serovar Typhimurium (no rank) [taxon 90371], Salmonella enterica (species) [taxon 28901], Salmonella enterica subsp. enterica serovar Enteritidis (no rank) [taxon 149539], Salmonella enterica subsp. enterica serovar Typhi (no rank) [taxon 90370]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12913687/full.md

## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913687/full.md

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Source: https://tomesphere.com/paper/PMC12913687