# Manipulating DNA repair and the DNA damage response to improve cancer therapy

**Authors:** Li Lan, Elise Fouquerel

PMC · DOI: 10.1093/narcan/zcag006 · NAR Cancer · 2026-02-18

## Full-text entities

- **Genes:** RAD51 (RAD51 recombinase) [NCBI Gene 5888] {aka BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2}, APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2) [NCBI Gene 27301] {aka APE2, APEXL2, XTH2, ZGRF2}, PARP1 (poly(ADP-ribose) polymerase 1) [NCBI Gene 142] {aka ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1}, SYCP2 (synaptonemal complex protein 2) [NCBI Gene 10388] {aka SCP-2, SCP2, SPGF1}, ATR (ATR checkpoint kinase) [NCBI Gene 545] {aka FCTCS, FRP1, MEC1, SCKL, SCKL1}, MLH1 (mutL homolog 1) [NCBI Gene 4292] {aka COCA2, FCC2, HNPCC, HNPCC2, LYNCH2, MLH-1}, PARG (poly(ADP-ribose) glycohydrolase) [NCBI Gene 8505] {aka PARG99}, PRMT5 (protein arginine methyltransferase 5) [NCBI Gene 10419] {aka HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs}, TOPBP1 (DNA topoisomerase II binding protein 1) [NCBI Gene 11073] {aka Dpb11, TOP2BP1}, ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) [NCBI Gene 25] {aka ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL}, PRKDC (protein kinase, DNA-activated, catalytic subunit) [NCBI Gene 5591] {aka DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC}, PRMT1 (protein arginine methyltransferase 1) [NCBI Gene 3276] {aka ANM1, HCP1, HRMT1L2, IR1B4}, TP53BP1 (tumor protein p53 binding protein 1) [NCBI Gene 7158] {aka 53BP1, TDRD30, p202, p53BP1}, MAD2L2 (mitotic arrest deficient 2 like 2) [NCBI Gene 10459] {aka FANCV, MAD2B, POLZ2, REV7}, APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1) [NCBI Gene 328] {aka APE, APE1, APEN, APEX, APX, HAP1}, SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1) [NCBI Gene 23583] {aka FDG, HMUDG, UNG3}, IDH1 (isocitrate dehydrogenase (NADP(+)) 1) [NCBI Gene 3417] {aka HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC}
- **Diseases:** Cancer (MESH:D009369), HR-deficient tumors (MESH:C535296), ovarian cancer (MESH:D010051)
- **Chemicals:** uracil (MESH:D014498), platinum (MESH:D010984), Base (-), m6A (MESH:C005955)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913588/full.md

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Source: https://tomesphere.com/paper/PMC12913588