# A case report of acute hyperlipidemic pancreatitis after blastocyst transfer and literature review

**Authors:** Minglin Liu, Hui Hu

PMC · DOI: 10.3389/fmed.2026.1698359 · Frontiers in Medicine · 2026-02-04

## TL;DR

A 28-year-old woman developed acute hyperlipidemic pancreatitis after a blastocyst transfer and was successfully treated with a combination of conventional and traditional Chinese medicine.

## Contribution

This case report highlights a rare complication of assisted reproduction and provides insights into its management.

## Key findings

- The patient was diagnosed with hyperlipidemic pancreatitis following blastocyst transfer.
- Treatment with plasmapheresis, insulin, fenofibrate, and traditional Chinese medicine led to significant improvement.
- The patient was successfully transferred to a general ward after initial ICU management.

## Abstract

A 28-year-old woman with a history of type 1 diabetes and non-alcoholic fatty liver disease (NAFLD) but no other significant past medical history, abdominal pain and nausea and vomiting 9 days after blastocyst transfer. She was diagnosed with Hyperlipidemic pancreatitis (HTGP) associated with assisted reproduction following comprehensive diagnostic evaluations and admitted to the ICU of our hospital.

Upon admission, the patient was managed with nil per os (NPO), plasmapheresis, and supplemental insulin. Medications administered included fenofibrate, ulinastatin, latamoxef (moxalactam), and the traditional Chinese medicine Mirabilite (Glauber’s salt). Fresh frozen plasma (FFP) and albumin were also transfused. Two days later, the patient’s relevant indicators decreased significantly and symptoms improved. The patient was subsequently transferred to the general ward for continued treatment.

## Linked entities

- **Chemicals:** fenofibrate (PubChem CID 3339), latamoxef (PubChem CID 47499), Mirabilite (PubChem CID 24436), Glauber’s salt (PubChem CID 1117)
- **Diseases:** type 1 diabetes (MONDO:0005147), non-alcoholic fatty liver disease (MONDO:0013209)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}
- **Diseases:** ascites (MESH:D001201), and abdominal mixed infections (MESH:D060085), atherosclerosis (MESH:D050197), neutrophilia (MESH:C563010), hypertension (MESH:D006973), polycystic ovary syndrome (MESH:D011085), VTE (MESH:D054556), infertility (MESH:D007246), OHSS (MESH:D016471), Leukocytosis (MESH:D007964), insulin deficiency (MESH:D007333), hypercholesterolemia (MESH:D006937), pregnancy loss (MESH:D000022), tenderness (MESH:D063806), T1DM (MESH:D003922), lipid (MESH:D011017), HTG (MESH:D015228), Cul-de-sac (MESH:D000082122), hyperlipidemia (MESH:D006949), hemoperitoneum (MESH:D006465), diseases (MESH:D004194), Inflammatory (MESH:D007249), biliary, alcoholic, and hyperlipidemic pancreatitis (MESH:D019512), epigastric pain (MESH:D010146), dyslipidemia (MESH:D050171), Diabetes (MESH:D003920), gallstones (MESH:D042882), cystic abnormalities (MESH:D018297), NAFLD (MESH:D065626), AP (MESH:D010195), abdominal pain (MESH:D015746), nausea (MESH:D009325), autoimmune pancreatitis (MESH:D000081012), hypercoagulable (MESH:D019851), metabolic dysregulation (MESH:D021081), metabolic derangements (MESH:D008659), vomiting (MESH:D014839), acute abdominal pain (MESH:D059787)
- **Chemicals:** Fresh (-), Glauber's salt (MESH:C012036), bicarbonate (MESH:D001639), lipid (MESH:D008055), alcohol (MESH:D000438), LMWH (MESH:D006495), fenofibrate (MESH:D011345), estradiol (MESH:D004958), TG (MESH:D014280), FFAs (MESH:D005230), Progesterone (MESH:D011374), enoxaparin (MESH:D017984), latamoxef (MESH:D009070), insulin (MESH:D007328), cholesterol (MESH:D002784)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** Q12H

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12913572/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12913572/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913572/full.md

---
Source: https://tomesphere.com/paper/PMC12913572