# Lifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review

**Authors:** Fujun Huang, Lei Tang, Xun Zhou, Qiang Fu, Yiping Lu

PMC · DOI: 10.3389/fpubh.2026.1739298 · Frontiers in Public Health · 2026-02-04

## TL;DR

This review explores how lifestyle factors like diet, sleep, and exercise may influence the development and progression of androgenetic alopecia.

## Contribution

The paper provides a comprehensive review of lifestyle factors and their potential mechanisms in androgenetic alopecia.

## Key findings

- Lifestyle factors such as diet and sleep may influence the progression of androgenetic alopecia.
- UV radiation and certain hairstyles could exacerbate the condition through specific pathogenic mechanisms.
- Exercise and healthy habits may help delay disease progression.

## Abstract

Androgenetic alopecia (AGA), which significantly impairs patients’ social interactions and psychological well-being, is widespread worldwide. Treatment of AGA is a long-term process that is difficult to stick to. Therefore, in the long-term management of AGA, establishing effective lifestyle intervention protocols to delay disease progression has become a central focus for both clinicians and patients. However, to the best of our knowledge, only limited and fragmented studies have characterized the impact of lifestyles on AGA. In this review, we focused on the impact of lifestyle factors, such as dietary habits, sleep patterns, ultraviolet radiation, exercise, and hairstyles, on AGA, and examined the underlying pathogenic mechanisms by which these factors may induce or exacerbate AGA.

## Linked entities

- **Diseases:** androgenetic alopecia (MONDO:0005339)

## Full-text entities

- **Genes:** ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide) [NCBI Gene 124] {aka ADH1}, PTGDR2 (prostaglandin D2 receptor 2) [NCBI Gene 11251] {aka CD294, CRTH2, DL1R, DP2, GPR44}, IL1A (interleukin 1 alpha) [NCBI Gene 3552] {aka IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1}, AKR1A1 (aldo-keto reductase family 1 member A1) [NCBI Gene 10327] {aka ALDR1, ALR, ARM, DD3, HEL-S-6}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, APC (APC regulator of Wnt signaling pathway) [NCBI Gene 324] {aka BTPS2, DESMD, DP2, DP2.5, DP3, GS}, AR (androgen receptor) [NCBI Gene 367] {aka AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1}, PTGES (prostaglandin E synthase) [NCBI Gene 9536] {aka MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, CCL2 (C-C motif chemokine ligand 2) [NCBI Gene 6347] {aka GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1}, PTGDS (prostaglandin D2 synthase) [NCBI Gene 5730] {aka L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2}, DVL1P1 (dishevelled segment polarity protein 1 pseudogene 1) [NCBI Gene 8215] {aka DVL-22, DVL1L1}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CRH (corticotropin releasing hormone) [NCBI Gene 1392] {aka CRF, CRH1}, CXXC5 (CXXC finger protein 5) [NCBI Gene 51523] {aka CF5, HSPC195, RINF, WID}, BMP4 (bone morphogenetic protein 4) [NCBI Gene 652] {aka BMP2B, BMP2B1, MCOPS6, OFC11, ZYME}, HNF4A (hepatocyte nuclear factor 4 alpha) [NCBI Gene 3172] {aka FRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha}, LRP1 (LDL receptor related protein 1) [NCBI Gene 4035] {aka A2MR, APOER, APR, CD91, DDH3, IGFBP-3R}, DKK1 (dickkopf Wnt signaling pathway inhibitor 1) [NCBI Gene 22943] {aka DKK-1, SK}, AKR1C3 (aldo-keto reductase family 1 member C3) [NCBI Gene 8644] {aka DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, TGFB2 (transforming growth factor beta 2) [NCBI Gene 7042] {aka CAEND2, G-TSF, LDS4, TGF-beta2}, PLA2G1B (phospholipase A2 group IB) [NCBI Gene 5319] {aka PLA2, PLA2A, PPLA2}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, GSK3B (glycogen synthase kinase 3 beta) [NCBI Gene 2932], PPARG (peroxisome proliferator activated receptor gamma) [NCBI Gene 5468] {aka CIMT1, FPLD3, GLM1, NR1C3, PPARG1, PPARG2}, COX8A (cytochrome c oxidase subunit 8A) [NCBI Gene 1351] {aka COX, COX8, COX8-2, COX8L, MC4DN15, VIII}, BMP1 (bone morphogenetic protein 1) [NCBI Gene 649] {aka OI13, PCOLC, PCP, TLD}, CSNK1A1 (casein kinase 1 alpha 1) [NCBI Gene 1452] {aka CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975}
- **Diseases:** hyperlipidemia (MESH:D006949), neurodegenerative diseases (MESH:D019636), Inflammatory (MESH:D007249), dermatoses (MESH:D012871), mitochondrial dysfunction (MESH:D028361), Sleep disturbance (MESH:D012893), sexual dysfunction (MESH:D012735), tumors (MESH:D009369), anxiety (MESH:D001007), Androgenetic alopecia (MESH:D000505), Obesity (MESH:D009765), Malassezia (MESH:D014010), weight gain (MESH:D015430), PG (MESH:C567786), overeating (MESH:D006963), hypoxia (MESH:D000860), malnutrition (MESH:D044342), carcinogenic (MESH:D011230), Insulin resistance (MESH:D007333), bone disorders (MESH:D001847), HF (MESH:D006201), depression (MESH:D003866), Extended sleep deprivation (MESH:D012892), degeneration of elastic (MESH:D009410), hypertrichosis (MESH:D006983), allergic reactions (MESH:D004342)
- **Chemicals:** fat (MESH:D005223), oxygen (MESH:D010100), zinc (MESH:D015032), PG (MESH:D011453), Cortisol (MESH:D006854), resorcinol (MESH:C031389), PGH2 (MESH:D044262), p-aminophenol (MESH:C026729), m-aminophenol (MESH:C055528), acetylcholine (MESH:D000109), PGE2 (MESH:D015232), Testosterone (MESH:D013739), iron (MESH:D007501), AA (MESH:D016718), acetic acid (MESH:D019342), alkaloid (MESH:D000470), norepinephrine (MESH:D009638), ceramides (MESH:D002518), cAMP (MESH:D000242), Ethanol (MESH:D000431), PGF2alpha (MESH:D015237), Melatonin (MESH:D008550), Porphyrin (MESH:D011166), DHT (-), Caffeine (MESH:D002110), finasteride (MESH:D018120), nicotine (MESH:D009538), p-phenylenediamine (MESH:C029728), spironolactone (MESH:D013148), minoxidil (MESH:D008914), melanin (MESH:D008543), lipid (MESH:D008055), dutasteride (MESH:D000068538), Alcohol (MESH:D000438), acetaldehyde (MESH:D000079), magnesium (MESH:D008274)
- **Species:** Cutibacterium acnes (species) [taxon 1747], Nicotiana tabacum (American tobacco, species) [taxon 4097], Malassezia (genus) [taxon 55193], Staphylococcus (genus) [taxon 1279], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** HF — Homo sapiens (Human), Hairy cell leukemia, Cancer cell line (CVCL_B401)

## Full text

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## Figures

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## References

129 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913381/full.md

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Source: https://tomesphere.com/paper/PMC12913381