# Iron deficiency and depression: evidence of critical risk periods

**Authors:** Ravi Philip Rajkumar

PMC · DOI: 10.3389/fpsyt.2026.1770460 · Frontiers in Psychiatry · 2026-02-04

## Full-text entities

- **Genes:** CP (ceruloplasmin) [NCBI Gene 1356] {aka AB073614, CP-2}, SLC40A1 (solute carrier family 40 member 1) [NCBI Gene 30061] {aka FPN, FPN1, HFE4, IREG1, MST079, MSTP079}, IDUA (alpha-L-iduronidase) [NCBI Gene 3425] {aka IDA, MPS1, MPSI}, Nr3c1 (nuclear receptor subfamily 3, group C, member 1) [NCBI Gene 14815] {aka GR, Grl-1, Grl1}, Hamp (hepcidin antimicrobial peptide) [NCBI Gene 84506] {aka Hamp1, Hepc, Hepc1}, HAMP (hepcidin antimicrobial peptide) [NCBI Gene 57817] {aka HEPC, HFE2B, LEAP1, PLTR}, TF (transferrin) [NCBI Gene 7018] {aka HEL-S-71p, PRO1557, PRO2086, TFQTL1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, TFRC (transferrin receptor) [NCBI Gene 7037] {aka CD71, IMD46, T9, TFR, TFR1, TR}
- **Diseases:** medical diseases (MESH:D000069279), Fatigue (MESH:D005221), mood disorders (MESH:D019964), white matter lesions (MESH:D056784), nutritional deficits (MESH:D009748), Iron deficiency (MESH:D000090463), anxiety disorders (MESH:D001008), Iron deficiency anemia (MESH:D018798), MDD (MESH:D003865), PPD (MESH:C535387), inflammation (MESH:D007249), reduced gastric acid secretion (MESH:D005764), anxiety (MESH:D001007), neuroinflammation (MESH:D000090862), blood loss (MESH:D016063), cancer (MESH:D009369), behavioral and emotional deficits (MESH:D001523), impaired (MESH:D060825), postpartum hemorrhage (MESH:D006473), dementia (MESH:D003704), bipolar disorder (MESH:D001714), Depression (MESH:D003866), neuronal damage (MESH:D009410), disability (MESH:D009069), cognitive impairment (MESH:D003072), nutrient deficiency (MESH:D007153), abnormalities in brain iron metabolism (MESH:D019189), anemia (MESH:D000740), infection (MESH:D007239), brain inflammation (MESH:D004660)
- **Chemicals:** Iron (MESH:D007501), aspirin (MESH:D001241), oxygen (MESH:D010100), dalteparin (MESH:D017985), allopregnanolone (MESH:D011280), steroids (MESH:D013256), fluoxetine (MESH:D005473), serotonin (MESH:D012701), dopamine (MESH:D004298), iron absorption (-), catecholamine (MESH:D002395)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12913190/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12913190/full.md

## References

82 references — full list in the complete paper: https://tomesphere.com/paper/PMC12913190/full.md

---
Source: https://tomesphere.com/paper/PMC12913190