# Natural Killer Cell Dysfunction Causes Eosinophil Accumulation in Chronic Rhinosinusitis With Nasal Polyps **Authors:** Yohei Sato, Daiki Nakashima, Natsuki Inoue, Erika Osada, Tomomitsu Hirota, Yasuhiro Tsunemi, Nobuyoshi Otori, Mamoru Yoshikawa, Mayumi Tamari, Tsuguhisa Nakayama PMC · DOI: 10.1002/clt2.70156 · Clinical and Translational Allergy · 2026-02-17 ## Full-text entities - **Genes:** SIGLEC8 (sialic acid binding Ig like lectin 8) [NCBI Gene 27181] {aka SAF2, SIGLEC-8, SIGLEC8L}, KLRK1 (killer cell lectin like receptor K1) [NCBI Gene 22914] {aka CD314, D12S2489E, KLR, NKG2-D, NKG2D}, FCGR3A (Fc gamma receptor IIIa) [NCBI Gene 2214] {aka CD16-II, CD16A, FCG3, FCGR3, FCRIIIA, FcGRIIIA}, IL13 (interleukin 13) [NCBI Gene 3596] {aka IL-13, P600}, NCR3 (natural cytotoxicity triggering receptor 3) [NCBI Gene 259197] {aka 1C7, CD337, LY117, MALS, NKp30}, NCR1 (natural cytotoxicity triggering receptor 1) [NCBI Gene 9437] {aka CD335, LY94, NK-p46, NKP46}, KLRC2 (killer cell lectin like receptor C2) [NCBI Gene 3822] {aka CD159c, NKG2-C, NKG2C}, PTPRC (protein tyrosine phosphatase receptor type C) [NCBI Gene 5788] {aka B220, CD45, CD45R, GP180, IMD105, L-CA}, NCAM1 (neural cell adhesion molecule 1) [NCBI Gene 4684] {aka CD56, MSK39, NCAM}, KLRC1 (killer cell lectin like receptor C1) [NCBI Gene 3821] {aka CD159A, NKG2, NKG2A} - **Diseases:** nasal and sinonasal inflammatory disease (MESH:D009668), Polyps (MESH:D011127), Chronic Rhinosinusitis (MESH:D000092562), atopic dermatitis (MESH:D003876), nasal obstruction (MESH:D015508), inflammation (MESH:D007249), CRSwNP (MESH:D009298), olfactory disturbances (MESH:D000857), NK dysfunction (MESH:D000077428) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Cell lines:** K562 — Homo sapiens (Human), Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Cancer cell line (CVCL_0004) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12912943/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12912943/full.md ## References 9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12912943/full.md --- Source: https://tomesphere.com/paper/PMC12912943