# Surgical Management of Symptomatic Progressive Monostotic Fibrous Dysplasia of the Rib: A Case Report

**Authors:** Anita Paiva, Rafael Martins, João Serra, Carlos Pinto, Pedro Fernandes

PMC · DOI: 10.7759/cureus.101797 · Cureus · 2026-01-18

## TL;DR

A patient with fibrous dysplasia of the rib experienced long-term symptom resolution after complete surgical removal, highlighting the need for long-term monitoring and potential surgical options.

## Contribution

Demonstrates the effectiveness of complete surgical excision for symptomatic progressive fibrous dysplasia of the rib after long-term follow-up.

## Key findings

- Complete surgical excision of the affected rib resolved persistent symptoms in a patient with progressive fibrous dysplasia.
- Late disease progression can occur even after partial resection, emphasizing the importance of long-term follow-up.
- Surgical intervention is a viable option for selected symptomatic cases of fibrous dysplasia involving the ribs.

## Abstract

Fibrous dysplasia is a benign skeletal disorder characterized by replacement of normal bone with fibrous tissue and immature bone, leading to bone fragility, deformity, and pain. The most common presentation is the monostotic form, which is frequently asymptomatic, whereas the polyostotic form is typically more extensive and symptomatic. Management is usually conservative, consisting of clinical and imaging surveillance and pain control, although selected symptomatic cases may benefit from surgical intervention. We report the case of a 33-year-old male who previously underwent partial resection of the left sixth rib due to an expansile bone lesion. Histopathological examination confirmed fibrous dysplasia, and the patient was discharged after one year of follow-up. Fifteen years later, he was referred to thoracic surgery due to persistent left-sided chest pain. Computed tomography demonstrated progression of fibrous dysplasia in the remaining segments of the left sixth rib. Given persistent symptoms, complete surgical excision of the affected rib was performed, resulting in full resolution of symptoms. This case highlights the potential for late disease progression in fibrous dysplasia, even after partial surgical resection, and underscores the importance of long-term follow-up. It also demonstrates that surgical excision can be an effective treatment option in selected symptomatic patients, including those with costal involvement.

## Linked entities

- **Diseases:** fibrous dysplasia (MONDO:0000845)

## Full-text entities

- **Genes:** GNAS (GNAS complex locus) [NCBI Gene 2778] {aka AHO, AIMAH1, C20orf45, GNAS1, GPSA, GSA}
- **Diseases:** pathological fractures (MESH:D005598), ossifying fibromas (MESH:D018214), deformity (MESH:D009140), rib (MESH:C537613), Fibrous Dysplasia of the Rib (MESH:C536393), HIV infection (MESH:D015658), aneurysmal bone cysts (MESH:D017824), giant cell tumours (MESH:D018286), bone lesion (MESH:D001847), costal fibrous dysplasia (MESH:D013991), endocrine dysfunction (MESH:D004700), infection (MESH:D007239), chest pain (MESH:D002637), pleural effusion (MESH:D010996), bone fragility (MESH:C536063), dysplastic (MESH:D004416), dysmorphia of the (MESH:C537340), fever (MESH:D005334), Langerhans cell histiocytosis (MESH:D006646), Fibrous dysplasia (MESH:D005357), bone pain (MESH:D010146), fracture (MESH:D050723), hereditary skeletal disorder (MESH:D009386), osteofibrous dysplasia (MESH:C563276), osteosarcoma (MESH:D012516), pigmentation (MESH:D010859), thoracic trauma (MESH:D013896), benign chest wall tumours (MESH:D009369), McCune-Albright syndrome (MESH:D005359), fibro-osseous lesion (MESH:D000070896), skeletal disorder (MESH:C564967)
- **Chemicals:** Bisphosphonates (MESH:D004164)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12912812/full.md

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Source: https://tomesphere.com/paper/PMC12912812