# A narrative review of impacts of apolipoproteins on atherosclerotic coronary plaques

## TL;DR

This review explores how different apolipoproteins affect coronary plaques and their potential as therapeutic targets.

## Contribution

The paper provides a narrative review of the clinical relevance of apolipoproteins in coronary plaque imaging and therapy.

## Key findings

- Apolipoproteins influence coronary plaque characteristics detectable through imaging.
- Therapeutic agents targeting apolipoproteins are being explored for clinical use.
- ApoA-I, ApoB, and ApoC-III have distinct roles in lipid metabolism and plaque formation.

## Abstract

Apolipoproteins are structural components of lipoproteins involved in assembly, enzyme regulation, structural integrity, and receptor binding. Apoprotein(a) forms lipoprotein(a), apolipoprotein A-I drives reverse cholesterol transport, apolipoprotein B reflects atherogenic particle number, and apolipoprotein C-III regulates triglycerides. This review highlights the clinical significance of these apolipoproteins in coronary plaque characteristics detected by imaging modality. Additionally, we summarize the current clinical status of therapeutic agents targeting these apolipoproteins and its future potential.