# Cardiometabolic health and ASCVD primary prevention: time to take actions

**Authors:** Jing Liu

PMC · DOI: 10.1038/s44325-025-00050-0 · npj Cardiovascular Health · 2025-05-03

## TL;DR

This paper emphasizes the importance of managing cardiometabolic disorders to prevent heart disease and introduces a new framework for improving global cardiovascular health.

## Contribution

The paper introduces Life’s Vital 9, a new concept for primary prevention of atherosclerotic cardiovascular disease.

## Key findings

- Cardiometabolic disorders are highly prevalent and critical to address for ASCVD prevention.
- Managing blood pressure, cholesterol, glucose, and lifestyle is essential for cardiovascular health.
- Sleep and mental health should be included in cardiovascular prevention strategies.

## Abstract

Cardiometabolic disorders is highly prevalent worldwide. Curbing the disorders is critical for atherosclerotic cardiovascular disease (ASCVD) primary prevention. High blood pressure, cholesterol and glucose management, and lifestyle modification are essential for cardiovascular health. Sleep and mental health should also be addressed. Life’s Vital 9, a new concept for ASCVD primary prevention, is proposed. Actions should be taken to control cardiometabolic disorders and to facilitate the improvement of global cardiovascular health.

## Linked entities

- **Diseases:** atherosclerotic cardiovascular disease (MONDO:1060134), high blood pressure (MONDO:0005044)

## Full-text entities

- **Genes:** GIP (gastric inhibitory polypeptide) [NCBI Gene 2695]
- **Diseases:** anxiety (MESH:D001007), diabetes (MESH:D003920), NAFLD (MESH:D065626), coronary heart diseases (MESH:D003327), dyslipidemia (MESH:D050171), CMM (MESH:D024821), hyperlipidemia (MESH:D006949), Disease (MESH:D004194), metabolic abnormalities (MESH:D008659), NCD (MESH:D000073296), stroke (MESH:D020521), overweight (MESH:D050177), obesity (MESH:D009765), weight loss (MESH:D015431), Mental and psychological abnormalities (MESH:D000067073), CVD (MESH:D002318), ASCVD (MESH:D050197), death (MESH:D003643), hypertension (MESH:D006973), SWDs (MESH:D009471), impaired glucose tolerance (MESH:D018149), high (MESH:D008228), depression (MESH:D003866), adiposity (MESH:D018205), hypercholesterolemia (MESH:D006937), type 2 diabetes (MESH:D003924)
- **Chemicals:** oxygen (MESH:D010100), salt (MESH:D012492), ezetimibe (MESH:D000069438), blood glucose (MESH:D001786), cholesterol (MESH:D002784), sodium (MESH:D012964), GLP-1RAs (-), glucose (MESH:D005947), alcohol (MESH:D000438), lipid (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12912436/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12912436/full.md

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Source: https://tomesphere.com/paper/PMC12912436