# Family history of premature CHD and risk factor control in patients with a recent ACS

**Authors:** Daniel Yu-Hung Jeng, Haeri Min, Simone Marschner, Desi Quintans, Julie Redfern, Harry Klimis, Graham Hillis, David Brieger, John Atherton, Ravinay Bhindi, Derek Chew, Nicholas Collins, Michael Fitzpatrick, Craig Juergens, Nadarajah Kangaharan, Andrew Maiorana, Michele McGrady, Rohan Poulter, Pratap Shetty, Christian Hamilton-Craig, Peter Thompson, Sandrine Stepien, Amy Von Huben, Shirley Jansen, Clara K. Chow

PMC · DOI: 10.1038/s44325-025-00060-y · npj Cardiovascular Health · 2025-07-15

## TL;DR

This study investigates whether knowing a family history of heart disease helps patients manage their health after a heart attack.

## Contribution

The study reveals that family history awareness does not improve risk factor control after acute coronary syndrome.

## Key findings

- Patients with a family history of premature CHD did not show better risk factor control at 12 months post ACS.
- No significant association was found between family history awareness and improved blood pressure or cholesterol control.
- New strategies are needed for secondary prevention in patients with a family history of premature CHD.

## Abstract

Individuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether patients with self-reported family history of premature CHD experiencing an acute coronary syndrome (ACS) were more likely to have their risk factors and health behaviours under control at 12 months post ACS. Data from the TEXTMEDS study were used to estimate the association between self-reported family history of premature CHD and blood pressure control, LDL cholesterol control, BMI, exercise and smoking status at 12 months post ACS. The study cohort consisted of 1423 participants (mean age 58.0 ± 10.67, 79.2% male), with 556 (39.1%) reporting a family history of premature CHD, while 867 (60.9%) reported no family history. No evidence from this analysis suggests that patients with knowledge of their family history were more likely to achieve better risk factor control. Novel strategies for risk factor control in this high-risk population is required to improve secondary prevention.

## Linked entities

- **Diseases:** coronary heart disease (MONDO:0005010), acute coronary syndrome (MONDO:0005542)

## Full-text entities

- **Diseases:** overweight (MESH:D050177), TEXTMEDS (MESH:D000068376), obesity (MESH:D009765), stenosis (MESH:D003251), physical disability (MESH:D059445), ACS (MESH:D054058), CHD (MESH:D003327), chronic kidney disease (MESH:D051436), diabetes (MESH:D003920), cardiac disease (MESH:D006331), depression (MESH:D003866), sleep apnoea (MESH:D012891), Hypertension (MESH:D006973), weight loss (MESH:D015431), Acute myocardial infarction (MESH:D009203), CVD (MESH:D002318)
- **Chemicals:** cholesterol (MESH:D002784), triglyceride (MESH:D014280), lipid (MESH:D008055), alcohol (MESH:D000438), ACEi (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12912435/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12912435/full.md

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Source: https://tomesphere.com/paper/PMC12912435