# CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems **Authors:** José Luiz Araújo Santos, Vinícius Tenório Braga Cavalcante Pinto, Thales Eduardo da Silva Santos, Daniel Gomes Coimbra, Tiago Gomes de Andrade PMC · DOI: 10.1038/s44323-025-00064-y · npj Biological Timing and Sleep · 2026-01-09 ## TL;DR CCorGsDB is a database that identifies genes linked to circadian rhythms in the mouse and human central nervous systems and connects them to diseases and drugs. ## Contribution The novel contribution is a validated database of conserved circadian-related genes in the CNS with disease and drug associations. ## Key findings - A conserved set of 251 orthologs was identified, enriched for RNA processing and autism-related phenotypes. - The database links circadian genes to disease terms and CNS-active drugs with spatial profiles. - Time-series data validated co-expression networks across sixteen mouse brain regions. ## Abstract We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short–half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs. ## Linked entities - **Species:** Mus musculus (taxon 10090), Homo sapiens (taxon 9606) ## Full-text entities - **Genes:** Crtc1 (CREB regulated transcription coactivator 1) [NCBI Gene 382056] {aka Mect1, TORC-1, TORC1, mKIAA0616}, KDM5C (lysine demethylase 5C) [NCBI Gene 8242] {aka DXS1272E, JARID1C, MRX13, MRXJ, MRXS16, MRXSCJ}, Csnk1a1 (casein kinase 1, alpha 1) [NCBI Gene 93687] {aka 2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a, Csnk1a}, Rorb (RAR-related orphan receptor beta) [NCBI Gene 225998] {aka Nr1f2, RZR-beta, RZRB, Rorbeta, hstp}, Cacna1d (calcium channel, voltage-dependent, L type, alpha 1D subunit) [NCBI Gene 12289] {aka 8430418G19Rik, Cach3, Cacn4, Cacnl1a2, Cav1.3, Cchl1a}, DBP (D-box binding PAR bZIP transcription factor) [NCBI Gene 1628] {aka DABP, taxREB302}, Fbxl21 (F-box and leucine-rich repeat protein 21) [NCBI Gene 213311] {aka D630045D17Rik, FBL3B, FBXL3B, Psttm}, TIA1 (TIA1 cytotoxic granule associated RNA binding protein) [NCBI Gene 7072] {aka ALS26, TIA-1, WDM}, Per2 (period circadian clock 2) [NCBI Gene 18627] {aka mKIAA0347, mPer2}, MAP3K2 (mitogen-activated protein kinase kinase kinase 2) [NCBI Gene 10746] {aka MEKK2, MEKK2B}, Rock2 (Rho-associated coiled-coil containing protein kinase 2) [NCBI Gene 19878] {aka B230113H15Rik, ROKalpha, Rho-kinase, Rock-II, Rock2m, mKIAA0619}, KMT2C (lysine methyltransferase 2C) [NCBI Gene 58508] {aka HALR, KLEFS2, MLL3}, NR1D2 (nuclear receptor subfamily 1 group D member 2) [NCBI Gene 9975] {aka BD73, EAR-1R, REVERBB, REVERBbeta, RVR}, CLK4 (CDC like kinase 4) [NCBI Gene 57396], Rnf123 (ring finger protein 123) [NCBI Gene 84585] {aka Kpc1}, SLC8A2 (solute carrier family 8 member A2) [NCBI Gene 6543] {aka NCX2}, Cpsf6 (cleavage and polyadenylation specific factor 6) [NCBI Gene 432508] {aka 4733401N12Rik, CFIM, CFIM68, HPBRII-4, HPBRII-7}, HNRNPDL (heterogeneous nuclear ribonucleoprotein D like) [NCBI Gene 9987] {aka HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, LGMDD3}, HCFC1 (host cell factor C1) [NCBI Gene 3054] {aka CFF, HCF, HCF-1, HCF1, HFC1, MAHCX}, Ncoa3 (nuclear receptor coactivator 3) [NCBI Gene 17979] {aka 2010305B15Rik, Actr, Aib1, KAT13B, Rac3, Src3}, Fbxl3 (F-box and leucine-rich repeat protein 3) [NCBI Gene 50789] {aka FBK, Fbl3a, Fbxl3a, Ovtm, Play68}, Npas2 (neuronal PAS domain protein 2) [NCBI Gene 18143] {aka MOP4, bHLHe9}, PER1 (period circadian regulator 1) [NCBI Gene 5187] {aka PER, RIGUI, hPER}, Cry2 (cryptochrome circadian regulator 2) [NCBI Gene 12953] {aka D130054K12Rik}, AKT3 (AKT serine/threonine kinase 3) [NCBI Gene 10000] {aka MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma}, Tef (thyrotroph embryonic factor) [NCBI Gene 21685] {aka 2310028D20Rik}, Cry1 (cryptochrome circadian regulator 1) [NCBI Gene 12952] {aka Phll1}, Per1 (period circadian clock 1) [NCBI Gene 18626] {aka Hftm, Per, m-rigui, mPer1}, BMAL1 (basic helix-loop-helix ARNT like 1) [NCBI Gene 406] {aka ARNTL, ARNTL1, BMAL1c, JAP3, MOP3, PASD3}, Clock (clock circadian regulator) [NCBI Gene 12753] {aka 5330400M04Rik, KAT13D}, PER3 (period circadian regulator 3) [NCBI Gene 8863] {aka FASPS3, GIG13}, PER2 (period circadian regulator 2) [NCBI Gene 8864] {aka FASPS, FASPS1}, Ranbp2 (RAN binding protein 2) [NCBI Gene 19386] {aka A430087B05Rik, NUP358}, Nr1d2 (nuclear receptor subfamily 1, group D, member 2) [NCBI Gene 353187] {aka RVR, Rev-erb}, Csnk1d (casein kinase 1, delta) [NCBI Gene 104318] {aka 1200006A05Rik, D930010H05Rik}, Arnt (aryl hydrocarbon receptor nuclear translocator) [NCBI Gene 11863] {aka D3Ertd557e, Drnt, ESTM42, Hif1b, bHLHe2, mKIAA4051}, Dbp (D site albumin promoter binding protein) [NCBI Gene 13170], Cacnb4 (calcium channel, voltage-dependent, beta 4 subunit) [NCBI Gene 12298] {aka 3110038O15Rik, Cchb4, lh}, Hnrnpm (heterogeneous nuclear ribonucleoprotein M) [NCBI Gene 76936] {aka 2610023M21Rik, Hnrpm, mKIAA4193}, NR1D1 (nuclear receptor subfamily 1 group D member 1) [NCBI Gene 9572] {aka EAR1, REVERBA, REVERBalpha, THRA1, THRAL, ear-1}, NPAS2 (neuronal PAS domain protein 2) [NCBI Gene 4862] {aka MOP4, PASD4, bHLHe9}, Bmal2 (basic helix-loop-helix ARNT like 2) [NCBI Gene 272322] {aka 4632430A05Rik, Arntl2, CLIF, MOP9, bHLHe6}, CCNL2 (cyclin L2) [NCBI Gene 81669] {aka ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE}, DDX6 (DEAD-box helicase 6) [NCBI Gene 1656] {aka HLR2, IDDILF, P54, RCK, Rck/p54}, Csnk1e (casein kinase 1, epsilon) [NCBI Gene 27373] {aka CK1epsilon, CKIe, KC1epsilon, tau}, TEF (TEF transcription factor, PAR bZIP family member) [NCBI Gene 7008], Per3 (period circadian clock 3) [NCBI Gene 18628] {aka 2810049O06Rik, mPer3}, Rora (RAR-related orphan receptor alpha) [NCBI Gene 19883] {aka 9530021D13Rik, Nr1f1, ROR1, ROR2, ROR3, nmf267}, Zswim8 (zinc finger SWIM-type containing 8) [NCBI Gene 268721] {aka 2310021P13Rik, 4832404P21Rik, Kiaa0913, mKIAA0913}, PIAS1 (protein inhibitor of activated STAT 1) [NCBI Gene 8554] {aka DDXBP1, GBP, GU/RH-II, ZMIZ3}, CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4) [NCBI Gene 26504] {aka ACDP4, SLC70A4}, Bmal1 (basic helix-loop-helix ARNT like 1) [NCBI Gene 11865] {aka Arnt3, Arntl, BMAL1b, MOP3, bHLHe5, bmal1b'}, CTCF (CCCTC-binding factor) [NCBI Gene 10664] {aka CFAP108, FAP108, MRD21}, Nr1d1 (nuclear receptor subfamily 1, group D, member 1) [NCBI Gene 217166] {aka A530070C09Rik}, Rorc (RAR-related orphan receptor gamma) [NCBI Gene 19885] {aka Nr1f3, RORgamma, TOR, Thor}, Hlf (hepatic leukemia factor) [NCBI Gene 217082] {aka E230015K02Rik}, CRY1 (cryptochrome circadian regulator 1) [NCBI Gene 1407] {aka DSPD, PHLL1}, TRRAP (transformation/transcription domain associated protein) [NCBI Gene 8295] {aka DEDDFA, DFNA75, PAF350/400, PAF400, STAF40, TR-AP} - **Diseases:** neurodegenerative and behavioral disorders (MESH:D019636), ASD (MESH:D000067877), Neuropsychiatric disorders (MESH:D001523), autism (MESH:D001321) - **Chemicals:** ABA (MESH:D000040), butamben (MESH:C004605), ME (-) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Drosophila melanogaster (fruit fly, species) [taxon 7227] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12912365/full.md ## Figures 3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12912365/full.md --- Source: https://tomesphere.com/paper/PMC12912365