# Structural insights into a broadly reactive nanobody that binds pathogenic and non-pathogenic lagoviruses

**Authors:** Derin Kara, Marie Pancera, Gholamreza Hassanzadeh-Ghassabeh, Steve Schoonooghe, Veronika Masic, Lauren Hartley-Tassell, Biswa Prasanna Mishra, Thomas Ve, Thomas Haselhorst, Mark von Itzstein, Grant S. Hansman

PMC · DOI: 10.1128/jvi.01990-25 · Journal of Virology · 2026-01-08

## Full-text entities

- **Genes:** HBG1 (hemoglobin subunit gamma 1) [NCBI Gene 3047] {aka HBG-T2, HBGA, HBGR, HSGGL1, PRO2979}
- **Chemicals:** NiSO4 (MESH:C029938), His (MESH:D006639), EDTA (MESH:D004492), imidazole (MESH:C029899), water (MESH:D014867), HBGAs (-), A-trisaccharide (MESH:C069225), fucose (MESH:D005643), hydrogen (MESH:D006859), PBS (MESH:D007854)
- **Species:** Hare calicivirus (species) [taxon 1743398], Lagovirus (genus) [taxon 95339], Norovirus (genus) [taxon 142786], Homo sapiens (human, species) [taxon 9606], Rabbit hemorrhagic disease virus (no rank) [taxon 11976], Rabbit hemorrhagic disease virus-AST89 (no rank) [taxon 314538]
- **Cell lines:** Ast89 — Homo sapiens (Human), Astrocytoma, Cancer cell line (CVCL_LK72)

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12911892/full.md

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Source: https://tomesphere.com/paper/PMC12911892