# Identifying subgroups of frequent emergency department users: a latent class analysis with linked healthcare utilisation, cost and mortality outcomes in the UK

**Authors:** Richard Mattock, Chris Bojke, Samuel D Relton, Akshay Kumar, Chris Burton, Suzanne Mason, Sonia Saraiva, Robert West, William Lee, Christina van der Feltz-Cornelis, Catriona Marshall, Gerlinde Pilkington, Steven Ariss, Steven Dykes, Elspeth Guthrie

PMC · DOI: 10.1136/bmjph-2025-003920 · BMJ Public Health · 2026-02-16

## TL;DR

This study identifies three main subgroups of frequent emergency department users in the UK, differing in healthcare use, costs, and outcomes, to help design better-targeted interventions.

## Contribution

The first study to use latent class analysis on large-scale, multiyear ED datasets to identify consistent subgroups of frequent users.

## Key findings

- Three consistent subgroups of frequent ED users were identified across datasets.
- Subgroups varied significantly in healthcare utilization, costs, and mortality.
- A fourth subgroup showed different characteristics depending on the dataset used.

## Abstract

Frequent users (FUs) of emergency departments (EDs) attend repeatedly, placing a disproportionate burden on healthcare systems. Although known to be heterogeneous, there is limited international evidence characterising FU subpopulations or examining how healthcare costs and outcomes differ across groups. Advancing this understanding is important for developing tailored interventions to meet diverse care needs.

FUs were defined as individuals with ≥5 ED attendances/year. We used two large UK datasets: Hospital Episode Statistics (HES, 2016–2019) and the Centre for Urgent and Emergency Care database (CUREd, 2017–2020). Together, these included over 148 000 FUs from 5 million ED users. Latent class analysis (LCA) was used to identify FU subgroups based on attendance patterns, healthcare use and diagnostic characteristics.

We identified three consistent subgroups (HES and CUREd): (1) low-severity FUs (n=23 034, 43.2%; n=7081, 32.7%); (2) high-intensity FUs with mental health and neurological needs (n=6288, 11.8%; n=3456, 15.9%); (3) older FUs with chronic illness and high inpatient use (n=24 028, 45.0%; n=11 139, 51.4%). Subgroups differed substantially in healthcare utilisation, costs and mortality. A fourth class varied across datasets: in HES, it showed moderate morbidity and complex needs; in CUREd, high morbidity and high-intensity ED use.

This is the first FU study to apply LCA across large-scale, multiyear ED datasets, identifying a potentially universal subgroup structure. Current services focus on a narrow subset of high-intensity users. Additional tailored strategies are needed to address the full spectrum of FU needs.

## Full-text entities

- **Genes:** RRBP1 (ribosome binding protein 1) [NCBI Gene 6238] {aka ES/130, ES130, RRp, hES, p180}
- **Diseases:** epilepsy (MESH:D004827), disease (MESH:D004194), neurological conditions (MESH:D019636), injury (MESH:D014947), Parkinson's (MESH:D010300), coronary heart disease (MESH:D003327), FUs (MESH:D009404), hypertension (MESH:D006973), Mortality (MESH:D003643), morbidities (OMIM:614963), atrial fibrillation (MESH:D001281), vascular disease (MESH:D014652), COVID-19 (MESH:D000086382), diabetes (MESH:D003920), gastrointestinal (MESH:D005767), ear, nose and throat conditions (MESH:D004427), cancer (MESH:D009369), attention deficit hyperactivity disorder (MESH:D001289), psychoses (MESH:D011618), addiction (MESH:D019966), mental illness (MESH:D001523), Cardiovascular conditions (MESH:D002318), infection (MESH:D007239), asthma (MESH:D001249), central nervous system and gastrointestinal issues (MESH:D002493), Health (OMIM:603663), ED (MESH:D004630), heart failure (MESH:D006333), IMD (MESH:D012892), Respiratory conditions (MESH:D012131), mental health problems (MESH:D000076082), cardiac (MESH:D006331), chronic obstructive pulmonary disease (MESH:D029424), substance misuse (MESH:D009293), social problems (MESH:D019973), Mental health conditions (MESH:D000071069), chronic illness (MESH:D002908), frailty (MESH:D000073496), LCA (MESH:D000085343)
- **Chemicals:** FU (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12911696/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12911696/full.md

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Source: https://tomesphere.com/paper/PMC12911696