# An atypical case of jejunal gastrointestinal stromal tumour presenting as chronic anaemia

**Authors:** Shadin S A Abushara, Dawood D M Mahmood, Ahmed Haidaran

PMC · DOI: 10.1093/jscr/rjag069 · Journal of Surgical Case Reports · 2026-02-17

## TL;DR

A rare case of a jejunal tumor causing long-term anemia is described, emphasizing the need for thorough small intestine evaluation in unexplained anemia.

## Contribution

Highlights a rare presentation of jejunal GIST as a cause of chronic anemia and the diagnostic utility of cross-sectional imaging.

## Key findings

- A jejunal gastrointestinal stromal tumor was identified as the cause of chronic unexplained iron deficiency anemia.
- Computed tomography angiography and laparoscopy were key in diagnosing the jejunal mass.
- Histopathology confirmed a low-risk gastrointestinal stromal tumor.

## Abstract

Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms, most commonly arising in the stomach or small intestine. Jejunal GISTs are rare and may pose diagnostic challenges. We report a 44-year-old woman with a 3-year history of chronic unexplained iron deficiency anaemia and negative endoscopy. Computed tomography angiography suggested a jejunal lesion. Laparoscopy identified a well-circumscribed jejunal mass, which was resected. Histopathology confirmed a low-risk GIST. This case highlights the importance of considering small bowel pathology in persistent anaemia and the role of cross-sectional imaging or capsule endoscopy in timely diagnosis.

## Linked entities

- **Diseases:** gastrointestinal stromal tumours (MONDO:0011719), iron deficiency anaemia (MONDO:0001356)

## Full-text entities

- **Genes:** KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, ANO1 (anoctamin 1) [NCBI Gene 55107] {aka DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A}
- **Diseases:** soft tissue sarcomas (MESH:D012509), chronic iron deficiency anaemia (MESH:D000090463), gastrointestinal (GI) bleeding (MESH:D006471), Small bowel lesions (MESH:D015212), bleeding (MESH:D006470), anaemia (MESH:D000743), GI malignancies (MESH:D005770), weakness (MESH:D018908), mesenchymal neoplasms (MESH:D009369), chronic blood loss (MESH:D016063), jejunal lesion (MESH:D007579), rectal bleeding (MESH:D012002), abdominal pain (MESH:D015746), weight loss (MESH:D015431), chronic anaemia (MESH:C536761), GIST (MESH:D046152)
- **Chemicals:** PDS (MESH:D010165), iron (MESH:D007501)
- **Species:** Helicobacter pylori (species) [taxon 210], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12911506/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12911506/full.md

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Source: https://tomesphere.com/paper/PMC12911506