# The NIAID Discovery Portal: a unified search engine for infectious and immune-mediated disease datasets

**Authors:** Ginger Tsueng, Emily Bullen, Candice Czech, Dylan Welzel, Leandro Collares, Jason Lin, Everaldo Rodolpho, Zubair Qazi, Nichollette Acosta, Lisa M. Mayer, Sudha Venkatachari, Zorana Mitrović Vučičević, Poromendro N. Burman, Deepti Jain, Jack DiGiovanna, Maria Giovanni, Asiyah Lin, Wilbert Van Panhuis, Laura D. Hughes, Andrew I. Su, Chunlei Wu

PMC · DOI: 10.1128/msystems.01270-25 · mSystems · 2025-12-31

## TL;DR

The NIAID Discovery Portal is a centralized tool that helps researchers find and access infectious and immune-mediated disease datasets more easily.

## Contribution

The portal introduces a unified search engine with harmonized metadata to improve data findability and reusability for infectious and immune-mediated disease research.

## Key findings

- The portal integrates metadata from multiple repositories to enable user-friendly data discovery.
- It supports both exploratory browsing and precise searches for diverse data types.
- Standardized metadata and an API enhance data accessibility and reuse for the research community.

## Abstract

The National Institute of Allergy and Infectious Diseases (NIAID) Data Ecosystem Discovery Portal (https://data.niaid.nih.gov) provides a unified search interface for over 4 million data sets relevant to infectious and immune-mediated disease (IID) research. Integrating metadata from domain-specific and generalist repositories, the Portal enables researchers to identify and access data sets using user-friendly filters or advanced queries, without requiring technical expertise. The Portal supports discovery of a wide range of resources, including epidemiological, clinical, and multi-omic data sets and is designed to accommodate exploratory browsing and precise searches. The Portal provides filters, prebuilt queries, and data set collections to simplify the discovery process for users. The Portal additionally provides documentation and an API for programmatic access to harmonized metadata. By easing access barriers to important biomedical data sets, the NIAID Data Ecosystem Discovery Portal serves as an entry point for researchers working to understand, diagnose, or treat IID.

Valuable data sets are often overlooked because they are difficult to locate. The NIAID Data Ecosystem Discovery Portal fills this gap by providing a centralized, searchable interface that empowers users with varying levels of technical expertise to find and reuse data. By standardizing key metadata fields and harmonizing heterogeneous formats, the Portal improves data findability, accessibility, and reusability. This resource supports hypothesis generation, comparative analysis, and secondary use of public data by the IID research community, including those funded by NIAID. The Portal supports data sharing by standardizing metadata and linking to source repositories and maximizes the impact of public investment in research data by supporting scientific advancement via secondary use.

## Linked entities

- **Diseases:** infectious disease (MONDO:0005550)

## Full-text entities

- **Diseases:** immune-mediated disease (MESH:C567355), IID (MESH:D003141)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12911352/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12911352/full.md

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Source: https://tomesphere.com/paper/PMC12911352