# Primary Oral Tuberculosis of Tongue, Tonsil, and Labial Mucosa: A Rare Case Report

**Authors:** Yosief Yemane, Hailemichael Ghebremariam, Teklezghi Ainealem, Haben Daniel, Natnael Ghebregziabher

PMC · DOI: 10.1155/carm/6678465 · Case Reports in Medicine · 2026-02-17

## TL;DR

This paper reports a rare case of primary oral tuberculosis in a 40-year-old woman in Eritrea, emphasizing the need for early diagnosis and awareness among healthcare professionals.

## Contribution

The paper presents a rare case of primary oral TB involving the tonsil, tongue, and labial mucosa, diagnosed using molecular and microscopic methods.

## Key findings

- Primary oral TB is rare and often misdiagnosed due to limited diagnostic tools.
- TB should be considered in the differential diagnosis of chronic oral ulcers in endemic regions.
- Early diagnosis and treatment are crucial for managing this rare manifestation.

## Abstract

Tuberculosis (TB) is worldwide a leading cause of morbidity, mortality, and a major public health problem particularly in resource constrained countries. Extrapulmonary tuberculosis (EPTB) accounts for about 20% of all TB cases. Primary oral cavity TB is not only rare form of EPTB but also exists with its diagnostic challenges. To our knowledge, a small number of primary oral TB cases have been reported in literature, which is likely due to the limited diagnostic modalities and its rarity.

We report a 40‐year‐old female patient presented to Dekemhare hospital in Dekemhare, Southern zone, Eritrea, with ulcerated oral cavity lesions associated with painful eating and swallowing. The diagnosis of oral TB involving tonsil, tongue, and labial mucosa was confirmed with Ziehl–Neelsen method and GeneXpert MTB/RIF molecular test from pus scrubbed from the lesions. The patient was treated with current anti‐TB regimen.

Since TB can affect any site of the body, high degree of suspicion is very important in its diagnosis. This case underscores the importance of considering TB in the differential diagnosis of chronic oral ulcers, especially in endemic regions, and highlights the need for awareness among oral health professionals to facilitate early diagnosis and management of this rare manifestation.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076)

## Full-text entities

- **Diseases:** periodontitis (MESH:D010518), trauma (MESH:D014947), syphilis (MESH:D013587), mouth ulcers (MESH:D019226), painful (MESH:D010146), alcohol (MESH:D000437), Venereal Disease (MESH:D012749), malignant tumors (MESH:D009369), diabetes (MESH:D003920), pulmonary (MESH:D008171), HPF (MESH:D007922), EPTB (MESH:D000092225), Human immunodeficiency virus/acquired immunodeficiency syndrome (MESH:D000163), lesions (MESH:D009059), oral cavity (MESH:D009062), hyperemia (MESH:D006940), fever (MESH:D005334), TB lymph adenitis (MESH:D008199), lichen planus (MESH:D008010), nosocomial infections (MESH:D003428), death (MESH:D003643), malnutrition (MESH:D044342), hematological disorders (MESH:D006402), Wegner's granulomatosis (MESH:D014890), infected (MESH:D007239), pulmonary TB (MESH:D014397), COVID-19 (MESH:D000086382), weight loss (MESH:D015431), chronic cough (MESH:D003371), ulcer (MESH:D014456), Oral Tuberculosis (MESH:D014393), miliary TB (MESH:D014391), TB (MESH:D014376), granulomas (MESH:D006099), fungal (MESH:D009181), pemphigus (MESH:D010392), HIV infection (MESH:D015658), tonsillitis (MESH:D014069), aphthous ulcers (MESH:D013281), Labial Mucosa (MESH:D006560), infectious (MESH:D003141), chronic cougher (MESH:D002908)
- **Chemicals:** doxycycline (MESH:D004318), isoniazid (MESH:D007538), pyridoxine (MESH:D011736), orabase (MESH:C056627), GeneXpert (-), prednisolone (MESH:D011239), ethambutol (MESH:D004977), Rifampicin (MESH:D012293), nystatin (MESH:D009761)
- **Species:** hepatitis C virus [taxon 11103], Human immunodeficiency virus 1 (no rank) [taxon 11676], Mycobacterium tuberculosis (species) [taxon 1773], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12910516/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12910516/full.md

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Source: https://tomesphere.com/paper/PMC12910516