# Hypertrophic Osteopathy Associated With Intrathoracic Masses in 5 Dogs and Review of the Literature **Authors:** Mehmet Alper Cetinkaya, Soner Cagatay, Mehmet Pilli, Ali Curukoglu, Deniz Seyrek Intas PMC · DOI: 10.1155/vmi/1441615 · Veterinary Medicine International · 2026-02-17 ## TL;DR This paper reports on 5 dogs with lung and chest masses that developed a bone condition called hypertrophic osteopathy and reviews what is known about the disease. ## Contribution The study adds new clinical cases of hypertrophic osteopathy in dogs with intrathoracic masses and updates the literature review. ## Key findings - Five female adult dogs with pulmonary and mediastinal masses showed hypertrophic osteopathy. - Clinical and radiographical findings were documented for each case. - The literature review summarizes historical and current knowledge on the disease. ## Abstract This study describes the clinical and radiographical findings of hypertrophic osteopathy in 5 female mature adult dogs with pulmonary and mediastinal masses. Besides, the literature review from the past to today provides information about the disease. ## Full-text entities - **Genes:** EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF} - **Diseases:** arthritis (MESH:D001168), metastases (MESH:D009362), died (MESH:D003643), infected (MESH:D007239), cardiovascular shunts (MESH:D002318), patent ductus arteriosus (MESH:D004374), dirofilariasis (MESH:D004184), arthralgia (MESH:D018771), bone abnormalities (MESH:D001847), subcutaneous lipoma (MESH:D013352), osteoporosis deformans (MESH:D010024), Congenital heart disease (MESH:D006330), Dirofilaria immitis (MESH:D003047), mammary carcinomas (MESH:D001943), abdominal mass (MESH:D000007), aortic valvular endocarditis (MESH:D004696), embryonal rhabdomyosarcoma of the esophagus (MESH:D018233), HO (MESH:D002312), cyanotic heart disease (MESH:D006331), pulmonary and mediastinal masses (MESH:D008477), Spirocerca lupi granulomas (MESH:D006099), cardiovascular system abnormalities (MESH:D018376), ovarian neoplasia (MESH:D010049), Marie's disease (MESH:D002607), Inflammation (MESH:D007249), pulmonary infections (MESH:D012141), Pachydermoperiostosis (MESH:D010004), cranio-osteoarthropathy (MESH:C537339), lameness (MESH:D007794), painful (MESH:D010146), Metastatic pulmonary neoplasms (MESH:D008175), liver adenocarcinoma (MESH:D000230), neoplasia (MESH:D009369), lung disease (MESH:D008171), congenital megaesophagus (MESH:D004931), edema (MESH:D004487), granulomatous disease (MESH:D006105), hypoxic (MESH:D002534), pulmonary arteriovenous shunts (MESH:C562451), ventricular septal defect (MESH:D006345), botryoid rhabdomyosarcoma of the urinary bladder (MESH:D001745), sarcoma (MESH:D012509), Marie-Bamberger syndrome (MESH:D010005), pulmonary masses (MESH:C536030), adrenocortical carcinoma (MESH:D018268) - **Chemicals:** CrCa (-), bisphosphonates (MESH:D004164), octreotide (MESH:D015282) - **Species:** Homo sapiens (human, species) [taxon 9606], Paragonimus westermani (species) [taxon 34504], Hepatozoon sp. (species) [taxon 1484059], Canis lupus familiaris (dog, subspecies) [taxon 9615], Cryptococcus neoformans (Cryptococcus neoformans serotype A, species) [taxon 5207] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12910252/full.md ## Figures 6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12910252/full.md ## References 66 references — full list in the complete paper: https://tomesphere.com/paper/PMC12910252/full.md --- Source: https://tomesphere.com/paper/PMC12910252