# Understanding the Current State of Play of Early Intervention for Bipolar Disorder: Qualitative Analysis of Consultations With International Stakeholders

**Authors:** Sue M. Cotton, Vani Jain, Aswin Ratheesh, Clare Shelton, Craig Macneil, Kate M. Filia, Jacob Crouse, Annabel Burnside, Emily Clarke, Alesha Prasad, Rosie Arnold, Paul Badcock, Melissa Hasty

PMC · DOI: 10.1111/bdi.70091 · Bipolar Disorders · 2026-02-16

## TL;DR

This study explores challenges in early intervention for bipolar disorder by consulting international experts and stakeholders.

## Contribution

The study identifies nine key challenges hindering early intervention for bipolar disorder through stakeholder interviews.

## Key findings

- Nine themes were identified as challenges in early intervention for bipolar disorder.
- Data saturation was achieved with 28 participants, suggesting key insights were captured.
- The study proposes a collaborative research framework to advance early intervention for bipolar disorder.

## Abstract

Despite the burden associated with bipolar disorder (BD), research into early diagnosis and treatment of BD lags approximately 20 years behind the field of early intervention for psychosis. This study evolved through a partnership between Orygen (Melbourne, Australia) and the Daymark Foundation (Toronto, Canada). The primary focus was to answer the question: “How might we advance an early intervention approach for people at‐risk of or with BD?”.

Semi‐structured interviews were conducted with international experts and other stakeholders in early intervention and BD to identify challenges and barriers in early intervention approaches to BD.

Twenty‐eight experts participated. Nine themes emerged as challenges: (i) limited recognition and understanding of BD across stakeholders; (ii) lack of definitions; (iii) poor resourcing and lack of prioritisation in funding models; (iv) absence of validated tools for diagnosis, monitoring treatment response and/or disorder progression; (v) absence of “big data”; (vi) scarcity of evidence‐based treatments and clinical guidelines for the early stages of the disorder; (vii) obscurity around optimal service models; (viii) the need for better support and involvement of families and significant others; and (ix) the need for collaboration (across disciplines, stakeholders, and settings) to progress the field.

Of those approached, 54.9% participated in the study. Given the qualitative nature of the study, recruiting more experts to the study would not necessarily change the outcomes as data saturation was achieved.

This work lays the foundations for developing a collaborative research framework to progress early intervention for young people with BD.

## Linked entities

- **Diseases:** bipolar disorder (MONDO:0004985)

## Full-text entities

- **Diseases:** hypersomnia (MESH:D006970), mental health disorder (OMIM:603663), cardiovascular disease (MESH:D002318), EIP (MESH:D011618), ADHD (MESH:D001289), dysphoric hypomania (MESH:C565864), Bipolar Disorder (MESH:D001714), depressed (MESH:D003866), Hypomania (MESH:D000087122), unstable mood (MESH:D000789), CBT (MESH:D003072), motor dysfunction (MESH:D000068079), borderline personality disorder (MESH:D001883), inflammatory (MESH:D007249), metabolic syndrome (MESH:D024821), autism (MESH:D001321), schizophrenia (MESH:D012559), irritable (MESH:D001523), mood (MESH:D019964), Weight gain (MESH:D015430), white matter alterations (MESH:D056784)
- **Chemicals:** mood stabilisers (-), melatonin (MESH:D008550), Lithium (MESH:D008094)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

69 references — full list in the complete paper: https://tomesphere.com/paper/PMC12910188/full.md

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Source: https://tomesphere.com/paper/PMC12910188