# Findings on Impact of Circadian Genes and Bipolar Disorder: A Bibliometric Analysis From 1996 to 2024

## TL;DR

This study maps global research trends on circadian genes and bipolar disorder from 1996 to 2024, showing rising interest and key research areas like depression, light therapy, and sleep.

## Contribution

A comprehensive bibliometric analysis of global research trends and hotspots in circadian genes and bipolar disorder from 1996 to 2024.

## Key findings

- The number of publications on circadian genes and bipolar disorder has grown at a 9.88% annual rate.
- Research hotspots include depression, light therapy, lithium treatment, and genetic associations.
- Emerging trends focus on sleep patterns, brain functions, and risk factors in bipolar disorder.

## Abstract

The disturbances of circadian genes are implicated in the pathophysiology of bipolar disorder (BD). This bibliometric analysis aims to explore global trends and hotspots in research on circadian genes and BD.

A bibliometric analysis.

A systematic search was carried out on the Web of Science Core Collection (WoSCC) database to collect publications regarding circadian genes and BD. Subsequently, bibliometric analysis and visualization utilized VOSviewer (V 1.6.20), CiteSpace (V 6.3.R1), and the R package “Bibliometrix” (V 4.3.3).

The 400 articles involved 2405 authors from 1649 institutions, citing 18,840 sources in 166 journals. The number of publications has been consistently rising, with a 9.88% annual growth rate. The USA, Italy, and China dominated with the most articles. The most cited articles focused on the genetics of circadian disorders. The top institutions were the University of California system, the University of California, San Diego, and Université Paris. High‐impact authors included McClung Colleen A., McCarthy Michael J., and Benedetti Francesco. The top journals by H‐index were Chronobiology International, Journal of Affective Disorders, and American Journal of Medical Genetics. The keyword co‐occurrence analysis revealed focus on “depression,” “neurons,” “light therapy,” “genome wide association,” and “lithium.” The burst keywords highlighted the latest trends, including “sleep” and “brain,” with consistent emphasis on “risk.”

This bibliometric analysis provides insights into the global trends and hotspots of research on circadian genes and BD. The hotspots are on symptoms, genetic associations, and treatment in BD, with frontiers exploring sleep patterns, brain functions, and risk factors.

This study maps global research trends on circadian genes and bipolar disorder from 1996 to 2024 using bibliometric methods. Analysis of 400 articles reveals a steady growth in publications, with the USA, Italy, and China as leading contributors. Key research hotspots include depression, neuronal mechanisms, light therapy, genetic associations, and lithium treatment, with emerging focus on sleep, brain function, and risk factors. Major clusters represent clinical symptoms, molecular mechanisms, therapeutic strategies, genetic studies, and animal models. Findings provide insights for future research and clinical practice in psychiatric genetics.