# Case Report: Thrombosed Mitral Leaflets in a Patient With Rheumatic Heart Disease: A Rare Clinical Case

**Authors:** Naser Khezerlou, Mehdi Taghizadeh, Mohammadjavad Sotoudeheian, Razieh Parizad

PMC · DOI: 10.1002/ccr3.72082 · 2026-02-16

## TL;DR

An 82-year-old man with rheumatic heart disease had a rare case of thrombosed mitral valve leaflets, which improved with anticoagulation therapy.

## Contribution

This case report highlights the rare occurrence of thrombosed mitral leaflets in rheumatic heart disease and the effectiveness of anticoagulation therapy.

## Key findings

- Transesophageal echocardiography identified a thrombus on the mitral valve leaflets.
- Anticoagulation therapy led to significant resolution of the thrombus.
- The case suggests thrombolytic and anticoagulation treatments may be effective in such rare scenarios.

## Abstract

Rheumatic heart disease remains a significant contributor to cardiovascular morbidity. We report the case of an 82‐year‐old man who presented with acute right‐sided hemiplegia. Transesophageal echocardiography (TEE) showed a thrombus attached to the mitral valve leaflets (MVL). Anticoagulation therapy was initiated, leading to significant thrombus resolution. It spotlights the potential efficacy of thrombolytic and anticoagulation.

Committee Approval Number: IR.TBZMED.REC.1403.1018

## Linked entities

- **Diseases:** rheumatic heart disease (MONDO:0006955)

## Full-text entities

- **Genes:** PLAT (plasminogen activator, tissue type) [NCBI Gene 5327] {aka T-PA, TPA}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** pleural effusions (MESH:D010996), intracranial hemorrhage (MESH:D020300), bleeding (MESH:D006470), dysarthria (MESH:D004401), MS (MESH:D008946), pneumonia (MESH:D011014), blood stasis (MESH:D014647), cerebrovascular accident (MESH:D020521), hypercoagulability (MESH:D019851), ischemia (MESH:D007511), MV (MESH:D008944), inflammation (MESH:D007249), Virchow's triad (MESH:D007619), volume loss (MESH:D016388), Parkinson's disease (MESH:D010300), ischemic (MESH:D002545), facial weakness (MESH:D018908), valve (MESH:D006349), cardioembolic complications (MESH:D000083262), embolic (MESH:D004617), infective endocarditis (MESH:D004696), wheezes (MESH:D012135), RHD (MESH:D012214), CHF (MESH:D006333), erythematous papules (MESH:D000169), microangiopathic (MESH:D000743), thromboembolic (MESH:D013923), granulomas (MESH:D006099), hemiplegia (MESH:D006429), systolic and diastolic failure (MESH:D054144), Thrombosed (MESH:D013927), gliosis (MESH:D005911), hypertension (MESH:D006973), ischemic stroke (MESH:D002544), AF (MESH:D001281), benign prostatic hyperplasia (MESH:D011470), murmur (MESH:D006337)
- **Chemicals:** oxygen (MESH:D010100), amitriptyline (MESH:D000639), warfarin (MESH:D014859), heparin (MESH:D006493), pantoprazole (MESH:D000077402), creatinine (MESH:D003404), levodopa (MESH:D007980), atorvastatin (MESH:D000069059), finasteride (MESH:D018120)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12909275/full.md

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Source: https://tomesphere.com/paper/PMC12909275