Association between ALDH2 rs671 polymorphism and susceptibility to non-valvular atrial fibrillation in a Chinese population: a large-scale case–control study
Fangming Zhong, Qifeng Zhang, Zhuolian Ye, Xuebo He, Junping Huang, Leiming Miao
TL;DR
This study finds that a genetic variant in ALDH2 is linked to a higher risk of non-valvular atrial fibrillation in a Chinese population.
Contribution
The study identifies ALDH2 rs671 polymorphism as an independent risk factor for non-valvular atrial fibrillation in a large Chinese cohort.
Findings
The A allele of ALDH2 rs671 is associated with increased risk of non-valvular atrial fibrillation (OR = 1.472).
GA and AA genotypes of ALDH2 rs671 are independent risk factors for non-valvular atrial fibrillation.
The association remains robust across multiple propensity score-matched cohorts.
Abstract
Non-valvular atrial fibrillation (NVAF) is the most common arrhythmia worldwide, with a steadily rising incidence and prevalence, posing a significant public health burden. Oxidative stress is recognized as a key driver of atrial remodeling and arrhythmogenesis. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a critical role in detoxifying reactive aldehydes, and the rs671 single-nucleotide polymorphism (G→A, Glu504Lys) markedly reduces enzymatic activity, with a high prevalence in East Asian populations. In this retrospective study, we analyzed 403 NVAF patients and 14,326 hospitalized controls from Meizhou People’s Hospital (2016–2020), aged ≥30 years (1:35.5 ratio), and constructed multiple propensity score-matched cohorts (1:15 to 1:2) to examine the association between ALDH2 rs671 and NVAF. The A allele frequency was significantly higher in NVAF patients than in the controls…
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Taxonomy
TopicsAlcohol Consumption and Health Effects · Atrial Fibrillation Management and Outcomes · Folate and B Vitamins Research