# PROTACs for Collateral Degradation: Is It Time to Back Up the Bus?

## TL;DR

This paper explores how off-target effects in certain drug-like molecules called PROTACs might actually be beneficial when targeting complex protein interactions.

## Contribution

The paper introduces the novel idea that collateral degradation by PROTACs could be advantageous in specific biological contexts.

## Key findings

- Off-target effects in PROTACs may be beneficial when targeting multiprotein complexes.
- The functional importance of protein complexes can outweigh the need for single-protein targeting.

## Abstract

Off-target effects are usually undesirable in drug development,
but for some PROTACs and other degraders, they may be advantageous.
Specifically, this can be so when the activities of multiprotein complexes
are more important than just the targeted protein of interest.