# VYC‐17.5L is Safe and Effective in Improving Skin Quality and Volume Deficit of Hands: Results From an 18‐Month Open‐Label Study

## TL;DR

VYC-17.5L is a safe and effective treatment for improving hand volume and skin quality, with benefits lasting up to 18 months.

## Contribution

Demonstrates the long-term safety and effectiveness of VYC-17.5L for hand rejuvenation.

## Key findings

- 100% of hands showed improvement in volume deficit at 3 months, with benefits lasting up to 18 months.
- Most participants reported improved self-perception of age and skin quality for at least 12 months.
- Treatment-related adverse events were mostly mild and did not lead to discontinuation.

## Abstract

Hands undergo age‐related changes in volume and skin quality. This 18‐month exploratory study evaluated safety and effectiveness of VYC‐17.5 L for hand rejuvenation.

Participants (≥ 35 years) with moderate‐to‐extreme Allergan Hand Volume Deficit Scale (AHVDS) scores received VYC‐17.5L in both hands on day 1, with optional touch‐up on day 30. Effectiveness was assessed by AHVDS responder rate (≥ 1‐grade improvement from baseline per hand) at months 1, 3 (primary effectiveness timepoint), and at 3‐month intervals through month 18; investigator‐ and participant‐Global Aesthetic Improvement Scale (GAIS); hand Self‐Perception of Age (SPA); and skin quality measurements. Safety was evaluated throughout.

Seventy‐five participants (94.7% female; mean age, 53.89 years) had both hands injected with VYC‐17.5L (median, 2.0 mL/hand), and 60.0% of hands received touch‐up (median, 1.0 mL/hand). The primary endpoint was met: 100.0% of hands were AHVDS responders at month 3. The 100% response rate was maintained through month 6, and the majority of participants (> 65%) were responders through month 18. Most hands (≥ 85%) improved on investigator‐ and participant‐GAIS through month 12. SPA improved by 5 to 6 years. Significant skin quality improvements persisted to 12 months. Twenty‐two (29.3%) participants experienced treatment‐related adverse events; most were mild or moderate in severity with a mean duration of 45.1 days, and none led to study discontinuation.

VYC‐17.5L is an effective treatment for improving hand volume deficit, with aesthetic benefits lasting 18 months.