Pathogenicity and Bioinformatics Analysis of Two GI‐13 Infectious Bronchitis Virus Strains in China
Juan Jin, Li Zhao, Yingjun Lv, Endong Bao
TL;DR
This study analyzed two new strains of infectious bronchitis virus in China, revealing differences in their pathogenicity and genetic makeup.
Contribution
The study identifies a virulent recombinant strain and a low-pathogenic variant within the same IBV lineage in China.
Findings
CK/CH/JS/2302 showed high virulence with severe symptoms and 10% mortality, while CK/CH/AH/2307 caused mild effects.
CK/CH/JS/2302 had a recombinant genome with high similarity to multiple genotypes, unlike CK/CH/AH/2307.
Amino acid substitutions in S1 protein HVRs may reduce vaccine cross-protection against these strains.
Abstract
Despite long‐term vaccination and control efforts, infectious bronchitis virus (IBV) remains a major threat to the global poultry industry, largely due to its high prevalence and extensive genetic diversity. This study aimed to characterize two novel GI‐13 (4/91‐like) IBV field strains, CK/CH/JS/2302 and CK/CH/AH/2307, isolated from H120‐vaccinated broiler flocks in China, in order to elucidate their pathogenicity, genomic characteristics, and evolutionary relationships. Although both isolates belonged to the GI‐13 genotype but exhibited divergent pathogenic profiles and evolutionary patterns. CK/CH/JS/2302 exhibited higher virulence, severe respiratory symptoms, tracheal hemorrhage, kidney lesions, and 10% mortality, while CK/CH/AH/2307 induced only mild respiratory signs and slight renal swelling. Phylogenetic analysis revealed that CK/CH/JS/2302 displayed a recombinant genome…
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Taxonomy
TopicsAnimal Virus Infections Studies · Respiratory viral infections research · Virology and Viral Diseases