# The role of human adipose-derived mesenchymal stem cell-derived exosomes in burn injury: a narrative review

## TL;DR

This review explores how exosomes from human fat cells can help heal burn injuries by reducing inflammation and promoting tissue repair.

## Contribution

The paper provides a comprehensive overview of the therapeutic potential of hADSCs-Exo in burn injury management.

## Key findings

- hADSCs-Exo promote wound healing through mechanisms like angiogenesis and inflammation reduction.
- They activate key signaling pathways such as PI3K/Akt and mTOR to enhance tissue repair.
- The review highlights the translational potential of hADSCs-Exo as a cell-free therapy for burns.

## Abstract

Burn injuries constitute a significant global health concern, presenting both health hazards and economic challenges. Recently, human adipose-derived mesenchymal stem cell exosomes (hADSCs-Exo) have emerged as a cell-free therapeutic strategy for promoting burn wound healing. These nano-sized particles function through various mechanisms, including promoting cellular migration, angiogenesis, inflammation reduction, immune response modulation, collagen remodeling, and scar prevention. They exert these effects by activating critical signaling pathways such as PI3K/Akt, IL-17RA/Smad, and mTOR. This review summarizes the biological characteristics and research relevance of hADSCs-Exo in burn injury management and discusses their translational implications.