# Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) and Mini-Mental (MMSE) in a Quilombola community with low education attainment: results of a cross-sectional study

**Authors:** João de Deus Cabral Júnior, Bruno Luciano Carneiro Alves de Oliveira, Sharon Sanz Simon, Jhule Silva Passinho, Carolina Cappi, Laiss Bertola, Candida Helena L. Alves, Vanda M. F. Simões, Gilberto Sousa Alves

PMC · DOI: 10.3389/frdem.2025.1673362 · 2026-02-02

## TL;DR

This study evaluates how well two cognitive tests work in a Brazilian community with low education to detect cognitive decline.

## Contribution

The study provides cutoff scores for cognitive tests in low-educated rural populations.

## Key findings

- The prevalence of mild cognitive impairment was 12.3% in the studied population.
- Both ACE-R and MMSE showed high accuracy (AUC = 0.96) in distinguishing MCI from healthy cognition.

## Abstract

Illiteracy may overestimate screening test interpretation for older adults with suspected cognitive decline. In rural areas of Brazil, the illiteracy rate and the lack of valid cognitive instruments may postpone the diagnosis of cognitive disorders.

To determine the diagnostic accuracy of the Addenbrooke’s Cognitive Examination (ACE-R) and Mini-Mental State Exam (MMSE) as well as the prevalence of mild cognitive impairment (MCI) for older adults with low education in a Quilombola community placed in Northeast Brazil, compared to cognitively healthy.

204 participants were collected from a sociodemographic and clinical evaluation and were subsequently the ACE-R and MMSE. Among them, 25 subjects presented MCI, and 179 were classified as cognitively healthy.

The prevalence of MCI was 12.3%; optimal accuracy yielded highest values for the comparison between controls and MCI for both ACE-R [Area Under the Curve (AUC) = 0.96] and MMSE (AUC = 0.96).

These findings support establishing reliable cutoff scores for cognitive assessment of older adults with low educational attainment, living in rural areas.

## Full-text entities

- **Genes:** AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}
- **Diseases:** cognitive decline (MESH:D003072), MCI (MESH:D060825)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12907204/full.md

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Source: https://tomesphere.com/paper/PMC12907204