Efficacy and safety of 3-month versus 6-month oxaliplatin-based adjuvant chemotherapy in colorectal cancer: a systematic review and meta-analysis

TL;DR

This study compares 3-month and 6-month oxaliplatin-based chemotherapy for colorectal cancer, finding similar survival but fewer side effects with the shorter regimen.

Contribution

The study provides new evidence on optimal chemotherapy duration for colorectal cancer based on stage and regimen type.

Findings

Three-month chemotherapy showed no significant difference in disease-free survival compared to six months.

Three-month regimen had higher completion rates and lower severe neuropathy.

Stage III patients on FOLFOX had worse disease-free survival with the three-month regimen.

Abstract

The optimal duration of oxaliplatin-based adjuvant chemotherapy for stage II–III colorectal cancer (CRC) remains uncertain. Although a 3-month regimen may reduce toxicity, particularly peripheral sensory neuropathy (PSN), its effect on long-term survival is unclear. This study systematically compared the efficacy and safety of 3 versus 6 months of oxaliplatin-based adjuvant chemotherapy in stage II–III CRC patients.

A systematic search of PubMed, Embase, the Cochrane Library, and Web of Science was conducted to identify randomized controlled trials (RCTs) comparing 3 months versus 6 months FOLFOX or CAPOX adjuvant chemotherapy in stage II–III CRC patients. Outcomes included disease-free survival (DFS), 3-year DFS rate, overall survival (OS), chemotherapy completion rate, and PSN. The certainty of evidence was evaluated using the GRADE approach, and trial sequential analysis (TSA) was performed to assess the robustness of the results.

Six RCTs involving a total of 16,420 stage II–III CRC patients were included. In the overall patients, the 3-month regimen showed no significant difference in DFS compared with the 6-month regimen (HR = 1.05, 95% CI 0.98–1.13, P = 0.18). Within the FOLFOX subgroup, the risk of DFS events was increased in the 3-month regimen (HR = 1.21, 95% CI 1.11–1.33, P < 0.001), with a similar difference observed among stage III patients (HR = 1.23, 95% CI 1.06–1.43, P = 0.007). No significant differences were observed in OS or 3-year OS rate, and all subgroup analyses showed no statistically significant differences in 3-year DFS rates. The 3-month regimen demonstrated a significantly higher chemotherapy completion rate, and grade 3–4 PSN was significantly lower in the 3 months regimen.

Stage II patients may preferentially receive a 3-month treatment regimen, whereas stage III patients receiving FOLFOX should still consider a 6-month regimen.

https://inplasy.com/inplasy-2025-12-0022/, identifier INPLASY-2025-12-0022.

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