# Factors influencing the proliferation of keratinocytes in psoriasis

## TL;DR

This paper reviews factors that cause skin cells to grow abnormally in psoriasis, aiming to improve understanding and treatment of the disease.

## Contribution

The paper systematically reviews multiple factors influencing keratinocyte proliferation in psoriasis.

## Key findings

- Inflammatory cytokines and immune microenvironment significantly affect keratinocyte proliferation.
- Epigenetics, metabolism, and autophagy also play roles in abnormal skin cell growth in psoriasis.
- The microbiome contributes to the complex pathogenesis of the disease.

## Abstract

The pathogenesis of psoriasis is extremely complex, and abnormal proliferation of keratinocytes (KCs) is one of its key pathological features. During the disease process, multiple factors can induce KC proliferation. This article reviews the mechanisms by which inflammatory cytokines, immune microenvironment, microbiome, epigenetics, metabolism, and the autophagy influence KC proliferation, aiming to provide insights for further research into the pathogenesis of psoriasis and the development of precise clinical treatments.

Health sciences