Vessel and balloon sizing in the IN.PACT AV access trial: post-hoc analysis of procedural characteristics and outcomes
Andrew Holden, Hiroaki Haruguchi, Kotaro Suemitsu, Naoko Isogai, Jeffrey Hull, Bret N. Wiechmann, Hong Wang, Bridget Wall, Robert Lookstein, Andrew Holden, Andrew Holden, Kotaro Suemitsu, Naoko Isogai, Jeffrey Hull, Bret N. Wiechmann, Levester Kirksey, Federico Parodi
TL;DR
This study analyzed how balloon and vessel sizing during a procedure affects outcomes for patients with dysfunctional arteriovenous fistulas used for dialysis.
Contribution
The study explores how intra-procedural sizing decisions may influence drug-coated balloon outcomes in fistula treatments.
Findings
Intra-procedural sizing decisions may positively impact outcomes in patients with dysfunctional fistula lesions.
Participants were grouped by median reference vessel diameter to assess primary patency outcomes.
The findings suggest the need for further research to define optimal drug-coated balloon sizing strategies.
Abstract
Drug-coated balloons (DCBs) have demonstrated effectiveness and safety in the treatment of dysfunctional arteriovenous fistulas used for hemodialysis in larger randomized studies; however, the patient and lesion profiles that have the best DCB outcomes remain undefined. Pivotal trials with core lab adjudication are ideal to generate hypotheses for future studies of intra-procedural characteristics given they include both site-reported and independently assessed data. The IN.PACT AV Access Trial randomized 330 patients 1:1 to treatment with a DCB (n = 170) or uncoated percutaneous transluminal angioplasty (PTA; n = 160). This exploratory post-hoc analysis investigated core lab adjudicated vessel sizing in the context of target lesion primary patency (TLPP) outcomes through 36 months. Participants were split into groups by median reference vessel diameter (RVD). The IN.PACT AV Access…
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Taxonomy
TopicsCentral Venous Catheters and Hemodialysis · Diagnosis and Treatment of Venous Diseases · Dialysis and Renal Disease Management