# Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

**Authors:** Sarah Zaki, Rédina Berkachy, Razan Zein Eddine, Mona Zeidan, Omar Obeid, Imad Toufeili, Elie-Jacques Fares

PMC · DOI: 10.1016/j.cdnut.2026.107637 · 2026-01-16

## TL;DR

This study found that drinking brewed yerba mate does not significantly boost metabolism or heart rate during light to moderate cycling, with body composition having a bigger impact.

## Contribution

The study is the first to compare commercial brewed yerba mate brands on cardiometabolic responses during exercise in healthy and overweight individuals.

## Key findings

- Brewed yerba mate did not significantly affect energy expenditure or substrate oxidation during cycling.
- Obesity status had a greater influence on physiological responses than yerba mate consumption.
- A significant three-way interaction was found for respiratory exchange ratio, mainly in men.

## Abstract

Yerba mate (Ilex paraguariensis) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed forms during exercise, particularly across different commercial brands.

This study aimed to evaluate and compare the acute effects of two commercially available brands of brewed yerba mate on substrate oxidation and energy expenditure in healthy and overweight/obese adults during very low- to moderate-intensity exercise.

A randomized crossover study comprising 29 healthy adults (15 men and 14 women) consumed 4 different drinks across separate visits: 2 commercially brewed yerba mate brands (AYM and KYM), water, and water with 135 mg caffeine. Following each drink, participants underwent graded cycling exercise while energy expenditure (EE), respiratory exchange ratio (RER), heart rate (HR), and delta efficiency (DE) were measured using indirect calorimetry.

Both yerba mate brands had similar caffeine concentrations but different phenolic content, yet neither significantly affected EE, substrate oxidation, HR, or DE during exercise compared to control drinks. Sex-based differences emerged, with women exhibiting higher RER and HR at similar workloads, but no drink × sex interactions were found. Obesity status influenced HR, EE, and DE, with obese participants showing altered physiological responses. A significant 3-way interaction (drink × intensity × sex) was observed for RER (P = 0.013), particularly in men. No drink × obesity interactions were detected.

Acute ingestion of brewed yerba mate, regardless of brand, did not enhance metabolic or cardiovascular responses during low- to moderate-intensity cycling. Body composition, particularly obesity status, had a more consistent influence on exercise efficiency than the short-term consumption of functional beverages like yerba mate.

## Linked entities

- **Chemicals:** caffeine (PubChem CID 2519)
- **Diseases:** obesity (MONDO:0011122)
- **Species:** Ilex paraguariensis (taxon 185542)

## Full-text entities

- **Diseases:** Obesity (MESH:D009765), overweight (MESH:D050177)
- **Chemicals:** Products (-), caffeine (MESH:D002110), water (MESH:D014867), polyphenol (MESH:D059808)
- **Species:** Homo sapiens (human, species) [taxon 9606], Ilex paraguariensis (mate, species) [taxon 185542]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12906188/full.md

---
Source: https://tomesphere.com/paper/PMC12906188