# Epididymal leiomyosarcoma: a case report

## TL;DR

This case report describes a rare epididymal leiomyosarcoma and emphasizes the importance of radical orchiectomy for effective treatment.

## Contribution

The paper adds a new case of epididymal leiomyosarcoma and reinforces the need for aggressive surgical intervention.

## Key findings

- Epididymal leiomyosarcoma is a rare and aggressive tumor with fewer than 30 global cases reported.
- Radical orchiectomy is recommended over simple epididymectomy to reduce recurrence rates.
- Imaging features like diffusion restriction and hypervascularity can aid in diagnosis.

## Abstract

Epididymal leiomyosarcoma is a rare, malignant neoplasm (Fisher et al. in Am J Surg Pathol 25(9):1143–9, 2001) characterized by rapid growth and aggressive behavior. Over the past decade, fewer than 30 cases of epididymal leiomyosarcoma have been reported globally.

In 2024, a male presented to the Fourth Affiliated Hospital of Zhejiang Universityl with a left scrotal mass. The patient underwent scrotal ultrasound and pelvic MRI, initially diagnosed with a hypervascular tumor of the epididymis; however, the precise nature of the tumor remained indeterminate before surgery. Following radical orchiectomy, postoperative pathology confirmed the diagnosis of epididymal leiomyosarcoma.

Although epididymal leiomyosarcoma represents a rare entity, it should be included in the differential diagnosis when patients present with a progressive scrotal mass demonstrating characteristic imaging features of diffusion restriction, heterogeneous hypoechogenicity, and hypervascularity. Notably, despite the well-demarcated contours and regular configuration of early-stage lesions, radical orchiectomy should be strongly recommended over simple epididymectomy given the tumor’s aggressive biological behavior. Simple epididymectomy is associated with higher recurrence rates. Long-term, rigorous surveillance remains paramount for disease management.