# With a little help from a friend – a new partner for acid-sensitive channels

**Authors:** Jochen Roeper

PMC · DOI: 10.1007/s00424-026-03154-3 · Pflugers Archiv · 2026-02-13

## Full-text entities

- **Genes:** Asic1 (acid-sensing ion channel 1) [NCBI Gene 11419] {aka ASIC, ASIC1a, ASIC1b, Accn2, B530003N02Rik, BNaC2}, Asic4 (acid-sensing ion channel family member 4) [NCBI Gene 241118] {aka Accn4, BNAC4}, Scnn1a (sodium channel, nonvoltage-gated 1 alpha) [NCBI Gene 20276] {aka ENaC, SCNEA, Scnn1, mENaC}, Pcyox1l (prenylcysteine oxidase 1 like) [NCBI Gene 240334] {aka C630049M13}, Asic2 (acid-sensing ion channel 2) [NCBI Gene 11418] {aka ACIC2, Accn1, BNC1, BNaC1, BNaC1a, Mdeg}, Canx (calnexin) [NCBI Gene 12330] {aka 1110069N15Rik, Cnx, D11Ertd153e}, Grin1 (glutamate receptor, ionotropic, NMDA1 (zeta 1)) [NCBI Gene 14810] {aka GluN1, GluRdelta1, GluRzeta1, M100174, NMD-R1, NMDAR1}
- **Diseases:** acidosis (MESH:D000138), Pseudomonas aeroginosa infection (MESH:D011552), neuropathic pain (MESH:D009437), pain (MESH:D010146), ischemia stroke (MESH:D007511), hypercapnia (MESH:D006935)
- **Chemicals:** D-Serine (-), farnesylcysteine (MESH:C057785), Na (MESH:D012964), geranylgeranylcysteine (MESH:C065977), protons (MESH:D011522), K (MESH:D011188), cysteine (MESH:D003545), acid (MESH:D000143)
- **Species:** Homo sapiens (human, species) [taxon 9606], Pseudomonas (RNA similarity group I, genus) [taxon 286], Mus musculus (house mouse, species) [taxon 10090]

## Full text

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Source: https://tomesphere.com/paper/PMC12904871