# DNAvi: integration, statistics, and visualization of cell-free DNA fragment traces

## TL;DR

DNAvi is a Python tool that quickly analyzes and visualizes cell-free DNA fragments from electrophoresis data, avoiding the need for sequencing.

## Contribution

DNAvi introduces a rapid, Python-based solution for analyzing and visualizing cell-free DNA fragment size profiles without sequencing.

## Key findings

- DNAvi enables normalization and statistical comparison of multiple cell-free DNA samples.
- The tool supports publication-ready plotting and quality control for fragmentomic screenings.

## Abstract

DNAvi is a Python-based tool for rapid grouped analysis and visualization of cell-free DNA fragment size profiles directly from electrophoresis data, overcoming the need for sequencing in basic fragmentomic screenings. It enables normalization, statistical comparison, and publication-ready plotting of multiple samples, supporting quality control and exploratory fragmentomics in clinical and research workflows.

DNAvi is implemented in Python and freely available on GitHub at https://github.com/anjahess/DNAvi under a GNU General Public License v3.0, along with source code, documentation, and examples. An archived version is available under https://doi.org/10.5281/zenodo.18401705.