# The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension

## TL;DR

This review explores how interactions between blood vessels and immune cells in the lung contribute to pulmonary hypertension and highlights the importance of the lung's environment in disease progression.

## Contribution

The paper offers an integrative perspective on pulmonary hypertension by emphasizing the role of vascular-immune cell communication and the microenvironment.

## Key findings

- Vascular-immune cell crosstalk is central to the progression of pulmonary hypertension.
- The pulmonary microenvironment plays a key role in shaping vascular remodeling.
- Disrupted cell communication is identified as a potential therapeutic target.

## Abstract

Pulmonary hypertension is a disease of the lung vasculature, which eventually leads to heart dysfunction. Despite the advances in the discovery and development of new treatments, most of them are aimed to palliate symptoms. Thus, it is crucial to identify novel potential targets directly acting on vascular remodeling. Further understanding of this pathological event is needed to completely describe the disease's mechanisms and effectively generate therapeutical strategies able to cure the disease. Here, we propose an integrative perspective of studying pulmonary hypertension based on the interactions between the vascular cells and their surroundings. This review describes the crosstalk between vascular cells and immune cells in the diseased vasculature, highlighting the central role of this axis and the importance of healthy cell‐to‐cell communication. Furthermore, we discuss the possibility of considering the pulmonary microenvironment as a key pathological factor in pulmonary hypertension.

This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic targets.