# Turning Everything Upside Down: The Impact of Illness on Romantic Relationships—A SEM‐Based Actor‐Partner Interdependence Model

**Authors:** Franziska Reinhardt, Imad Maatouk

PMC · DOI: 10.1111/famp.70129 · 2026-02-13

## TL;DR

This study explores how different illnesses affect both the ill person and their partner's well-being and relationship satisfaction.

## Contribution

The study introduces a systemic perspective using an extended APIM to analyze illness impacts on both partners in a relationship.

## Key findings

- Disease severity and duration negatively affect relationship satisfaction.
- Intimacy and constructive conflict resolution protect relationship satisfaction across illness types.
- Illness impacts show consistent patterns in partnerships regardless of the specific condition.

## Abstract

Illnesses are often associated with fundamental changes in relationship dynamics. Yet, little is known about how different acute and chronic conditions distinctly impact both partners' well‐being. This study analyzed the reciprocal associations between different illnesses on life satisfaction and relationship satisfaction in partnerships. Based on data from the Family Demographic Panel (FReDA), 14,426 people were analyzed in a two‐stage analysis process. In the first step, a Welch‐ANOVA examined disease‐specific differences in life satisfaction as a function of partnership status, focusing on the well‐being of the ill individual. In the second step, an extended Actor–Partner Interdependence Model (APIM) was applied to partnered dyads, shifting the focus to the healthy partner and analyzing how the illness of one partner and relational factors are associated with the partner's relationship and life satisfaction. The results revealed substantial crossover effects, with consistent partnership‐related patterns across illness types. Disease severity and duration were negatively associated with relationship satisfaction, whereas intimacy and constructive conflict resolution emerged as universal protective factors. These findings underscore the relevance of a systemic perspective in healthcare and show the need for partnership‐oriented interventions.

## Full-text entities

- **Diseases:** Chronic illnesses (MESH:D002908), kidney disease (MESH:D007674), cataract (MESH:D002386), Musculoskeletal disorders (MESH:D009140), cardiac invalidity (MESH:D006331), cholesterol (MESH:C535937), peptic ulcer (MESH:D010437), heart attack (MESH:D009203), Cardiovascular diseases (MESH:D002318), Health impairments (OMIM:603663), digestive disease (MESH:D004066), rheumatoid arthritis (MESH:D001172), hip fracture (MESH:D006620), hypertension (MESH:D006973), osteoarthritis (MESH:D010003), metabolic diseases (MESH:D008659), anxiety disorder (MESH:D001008), FReDA (MESH:D055191), APIM (MESH:D004195), stroke (MESH:D020521), chronic lung disease (MESH:D029424), diabetes (MESH:D003920), lung disease (MESH:D008171), Cancer (MESH:D009369), kidney failure (MESH:D051437), Mental illnesses (MESH:D001523), chronic kidney disease (MESH:D051436), asthma (MESH:D001249), work impairment (MESH:D000073397), stomach ulcer (MESH:D013276), Parkinson's disease (MESH:D010300), Fractures (MESH:D050723), pain (MESH:D010146), respiratory diseases (MESH:D012140)
- **Chemicals:** Badr (-), cholesterol (MESH:D002784)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12903840/full.md

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Source: https://tomesphere.com/paper/PMC12903840