Exploring the Potential Roles of Oxidative Stress–Related Genes in Thyroid Eye Disease and Graves’ Disease
Weili Zhang, Qinying Huang, Jinying Li
TL;DR
This study explores how oxidative stress-related genes may contribute to thyroid eye disease and Graves’ disease, identifying potential biomarkers and pathways.
Contribution
The study identifies 22 oxidative stress-related genes and proposes hub genes as potential diagnostic biomarkers for TED and GD.
Findings
22 oxidative stress-related differentially expressed genes were identified in TED and GD.
Hub genes DUSP1, EGR1, FOS, and JUNB were linked to immune cells and proposed as potential biomarkers.
A nomogram model showed good calibration for diagnostic purposes.
Abstract
To reveal the significance of oxidative stress–related genes in the pathogenesis of thyroid eye disease (TED) and Graves’ disease (GD) using a bioinformatics approach. Utilizing datasets from the GEO database, we used the “limma” package to detect differentially expressed genes (DEGs). Oxidative stress–related DEGs related to TED and GD were identified through cross‐referencing with the GeneCards database. We used a variety of methods, such as enrichment analyses, LASSO, RF techniques, PPI network analysis, and the CIBERSORT algorithm. We identified 22 oxidative stress–related DEGs related to TED and GD, primarily involved in miRNA transcription and regulation. Hub genes (DUSP1, EGR1, FOS, and JUNB) were linked to immune cells and were identified as potential diagnostic biomarkers. The developed nomogram model exhibited satisfactory calibration. This computational study sheds light…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsOphthalmology and Eye Disorders · Connexins and lens biology · Thyroid Disorders and Treatments