Liver senescence in focus: Heterogeneity across aging and cancer
Cleo L. Bishop
TL;DR
The paper explores how senescent cells differ across liver cell types during aging, fibrosis, and cancer.
Contribution
The study identifies cell-type- and context-specific signatures of senescent cells in the liver.
Findings
Senescent cell signatures vary by liver cell type and disease context.
The findings provide a valuable resource for future therapeutic development.
Abstract
How does senescent cell heterogeneity vary across different cell types in the liver in aging, fibrosis, and cancer? In Cell Genomics, Karpova and Li et al. reveal cell-type- and context-specific senescent cell signatures, offering the community a valuable resource and providing the potential for future therapeutic innovation. How does senescent cell heterogeneity vary across different cell types in the liver in aging, fibrosis, and cancer? In Cell Genomics, Karpova and Li et al. reveal cell-type- and context-specific senescent cell signatures, offering the community a valuable resource and providing the potential for future therapeutic innovation.
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Taxonomy
TopicsTelomeres, Telomerase, and Senescence · Single-cell and spatial transcriptomics · Liver physiology and pathology