Combining Gold and Selenium as Emerging Bioactive Compounds: From Synthesis to Therapeutic Potential
Katherine Lima Bruno, Patrícia Salvador Tessaro, Mariana F. Soares, Eduardo E. Alberto, Heveline Silva
TL;DR
This paper reviews how combining gold and selenium in chemical compounds can lead to new therapeutic applications, such as anticancer and anti-inflammatory effects.
Contribution
The paper provides a comprehensive overview of the synthesis and biological potential of selenium-containing gold compounds.
Findings
Selenium-containing gold compounds show anticancer, antimicrobial, and anti-inflammatory activities.
These compounds inhibit enzymes like thioredoxin reductase and disrupt redox homeostasis.
The synergy between gold and selenium is key to their biological effects.
Abstract
This review outlines an overview of selenium-containing gold compounds, framed within the context of gold chemistry. It emphasizes key synthetic strategies and structural features of Au–Se complexes, encompassing both gold(I) and gold(III) species. Various classes of selenium ligands are discussed, including selenols, selenoureas, selenones, and selenium-NHCs, among other organoselenium ligands. Despite the relatively limited number of studies, these complexes exhibit diverse biological activities, including anticancer, antimicrobial, and anti-inflammatory effects. Mechanistic evidence suggests that these activities primarily arise from inhibition of thiol- and selenol-containing enzymes (e.g., thioredoxin reductase), disruption of redox homeostasis, or the induction of reactive oxygen species (ROS) formation. The synergistic interplay between gold and selenium centers is crucial for…
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Taxonomy
TopicsOrganoselenium and organotellurium chemistry · Catalytic Alkyne Reactions · Trace Elements in Health