Poster Session II - A290 WITHDRAWAL OF TNF ANTAGONISTS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN REMISSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

TL;DR

This study finds that stopping TNF drugs in IBD patients in remission increases relapse risk but lowers infection risk.

Contribution

A meta-analysis of RCTs provides updated evidence on the risks and benefits of discontinuing TNF antagonists in IBD patients.

Findings

TNF withdrawal increases relapse risk compared to continuation (RR: 3.00).

Infection risk is reduced with TNF withdrawal (RR: 0.47).

Time to relapse is shorter after TNF discontinuation (HR: 5.34).

Abstract

Tumor necrosis factor (TNF) antagonists are central to the management of inflammatory bowel disease (IBD), but concerns regarding long-term safety, infection risk, and costs have prompted interest in treatment de-escalation. Whether discontinuing TNF therapy in patients with sustained remission is safe remains uncertain.

We aimed to conduct an updated systematic review and meta-analysis pooling all RCTs published to date on this subject in order to provide a more robust assessment of the risk of relapse, the likelihood of sustained clinical remission, and the incidence of adverse events among patients with IBD in sustained clinical remission on TNF-α antagonists. By synthesizing all available evidence, our study seeks to enhance statistical power and provide more reliable estimates to guide clinical decision-making.

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing TNF antagonist withdrawal with continuation in IBD patients in sustained remission. Databases including MEDLINE, Embase, CENTRAL, and ClinicalTrials.gov were searched through July 2025. Eligible trials enrolled adults with Crohn’s disease or ulcerative colitis in clinical remission. Primary outcomes were relapse risk and sustained remission. Data were pooled using a random-effects model.

Four RCTs comprising 485 patients were included. TNF antagonist withdrawal was associated with a significantly higher risk of relapse compared with continuation (RR: 3.00, 95% CI: 1.47–6.11). Time to relapse was also shorter in the withdrawal group (HR: 5.34, 95% CI: 2.05–13.92). Sustained clinical remission did not differ significantly between groups (RR: 0.83, 95% CI: 0.55–1.27). Withdrawal reduced infection risk (RR: 0.47, 95% CI: 0.25–0.90), while rates of gastrointestinal and serious adverse events were comparable.

Discontinuation of TNF antagonists in IBD patients in remission substantially increases the risk and accelerates the timing of relapse, though it lowers infection risk. Careful patient selection and close monitoring are essential if withdrawal is considered.

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