# A pathologically diagnosed multinodular and vacuolating neuronal tumor without typical multiple nodules: a case report

**Authors:** Ryota Kitano, Hiroaki Nagashima, Tomoaki Harada, Kazuhiro Tanaka, Keiichiro Uehara, Masamitsu Nishihara, Takashi Sasayama

PMC · DOI: 10.3389/fradi.2026.1718759 · Frontiers in Radiology · 2026-01-30

## TL;DR

This case report describes a rare pathologically confirmed multinodular and vacuolating neuronal tumor with radiological features resembling a low-grade glioma.

## Contribution

The paper presents a rare case of MVNT confirmed pathologically and highlights radiological features to differentiate it from low-grade glioma.

## Key findings

- MVNT was confirmed pathologically despite radiological similarity to low-grade glioma.
- Radiological features were identified to help distinguish MVNT from low-grade glioma.

## Abstract

Multinodular and vacuolating neuronal tumors (MVNT) are glioneuronal and neuronal tumors classified as grade 1 in the 2021 World Health Organization classification of central nervous system tumors. These tumors are characterized by multiple nodules located between the deep cortex and subcortical white matter. Typically, patients are diagnosed radiologically and do not require treatment. This report describes a rare case of pathologically confirmed MVNT with radiological findings similar to those of low-grade glioma. Moreover, we highlight radiological features useful for differentiating MVNT from low-grade glioma.

## Linked entities

- **Diseases:** low-grade glioma (MONDO:0021637)

## Full-text entities

- **Diseases:** glioma (MESH:D005910), glioneuronal and neuronal tumors (MESH:D009369), MVNT (MESH:C564546), central nervous system tumors (MESH:D016543)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12901476/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12901476/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12901476/full.md

---
Source: https://tomesphere.com/paper/PMC12901476