# The dual roles of ferroptosis in digestive tract tumors: mechanisms, microenvironment regulation, and therapeutic integration with emphasis on immune interactions

## TL;DR

This paper explores how ferroptosis, a type of cell death, can both help and hinder cancer progression in the digestive tract, focusing on its mechanisms and therapeutic potential.

## Contribution

The paper introduces a systematic analysis of ferroptosis's dual roles in digestive tract tumors, emphasizing immune interactions and therapeutic integration.

## Key findings

- Ferroptosis is linked to cancer progression and treatment resistance in digestive tract tumors.
- Ferroptosis influences the tumor microenvironment and immune interactions.
- Targeting ferroptosis shows potential for therapeutic strategies in gastrointestinal cancers.

## Abstract

Malignant tumors of the digestive tract are a major global health burden, characterized by high incidence and mortality rates, limited treatment options for advanced patients, and poor prognosis. Ferroptosis is an iron-regulated form of cell death driven by lipid peroxide (LPO) accumulation, and it is closely linked to the occurrence and progression of various cancers. Ferroptosis plays a critical role in the proliferation, metastasis, drug resistance, and microenvironment regulation of digestive tract cancer. This article will systematically examine the dual roles of ferroptosis through the core concepts of mechanism analysis, microenvironment regulation, and immune interactions, while exploring the therapeutic potential of targeting ferroptosis in the treatment of gastrointestinal malignancies.