# Recovery with vistula tart cherries following a marathon

**Authors:** Emma Squires, Ian. H. Walshe, Ashleigh Keenan, Oliver Hayman, Ishbel Lomax, Jacob Wood, Rosiered Brownson-Smith, Malachy. P. McHugh, Glyn Howatson

PMC · DOI: 10.1007/s00394-025-03847-y · European Journal of Nutrition · 2026-02-12

## TL;DR

This study tested whether Vistula tart cherries help marathon runners recover by reducing inflammation, though they didn't improve muscle function or soreness.

## Contribution

The study explores the Vistula cultivar of tart cherries for recovery, a cultivar not previously studied in this context.

## Key findings

- The marathon caused significant muscle damage and inflammation in all participants.
- Tart cherries reduced levels of high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation.
- No differences were found in muscle function or soreness between tart cherry and placebo groups.

## Abstract

Long-distance running induces marked increases in inflammation and muscle damage. Tart cherries (TC) have become a popular nutritional strategy for exercise recovery, particularly for attenuation of markers associated with muscle damage and inflammation.

Research question.

The aim of this study was to examine the effect of a yet-to-be-explored cultivar (Vistula) of TC on recovery following a marathon.

Thirty-five recreationally trained marathon runners (mean ± SD age, stature, and mass were 40 ± 10 years old, 176.5 ± 10.2 cm, and 78.8 ± 13.8 kg, respectively) completed an undulating marathon course. Participants were randomised to receive either freeze-dried TC powder or calorie-matched placebo (17 TC, 18 placebo) for 7 days, with the marathon on day 5 of supplementation. Maximal voluntary contractions (MVC), counter movement jumps (CMJ), muscle soreness (DOMS), plasma creatine kinase (CK), and high-sensitive C-reactive protein (hs-CRP) were assessed before, immediately after, and at 24- and 48-h post marathon.

There were significant changes over time for all variables (p < 0.001) indicating muscle damage. There were no treatment or interaction effects for MVC, CMJ, DOMS, and CK (p > 0.2). However, there was a treatment effect for hs-CRP, where the TC group experienced lower levels of hs-CRP (mean ± SD during recovery: TC 7.9 ± 3.5, placebo 12.5 ± 5.1 mg/L, p = 0.031).

The marathon caused changes in muscle damage and inflammation indices. Despite no functional or soreness differences, the TC group showed lower inflammation levels, offering insights into Vistula tart cherries for recovery.

The online version contains supplementary material available at 10.1007/s00394-025-03847-y.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}
- **Diseases:** inflammation (MESH:D007249), muscle damage (MESH:D009133), muscle soreness (MESH:D063806)
- **Chemicals:** TC (-), DOMS (MESH:D004290)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC12901211